INT280551

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 32 93.76 High High
Fibrositis 54 75.60 Quite High
Pain 9 46.12 Quite Low
Inflammation 4 35.44 Quite Low
drug abuse 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 90.04 High High
Obesity 41 76.80 Quite High
Leiomyosarcoma 59 76.36 Quite High
Fibromyalgia 54 75.60 Quite High
Malignant Neoplastic Disease 4 47.92 Quite Low
Pain 7 46.12 Quite Low
Fatigue 3 45.76 Quite Low
INFLAMMATION 6 35.44 Quite Low
Disease 13 15.72 Low Low
Overweight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When IL-6 binds to its receptor, a mechanism is triggered blocking Janus Kinase signal and activator of transcription (JAK/STAT) mediated transcription of IL-1 and TNF-?
Negative_regulation (blocking) of Gene_expression (signal) of Janus Kinase
1) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 0.65 Pain Relevance 0.37
In contrast, the growth of JAK1-transfected SKN cells, which had strong exogenous JAK1 activity, was prevented by IFN-?
Negative_regulation (prevented) of Gene_expression (growth) of JAK1
2) Confidence 0.30 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.37 Pain Relevance 0

General Comments

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