INT280553

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.46
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB9) nucleoplasm (PSMB9) peptidase activity (PSMB9)
small molecule metabolic process (PSMB9) nucleus (PSMB9) cellular nitrogen compound metabolic process (PSMB9)
PSMB9 (Homo sapiens)
PSMB9 - R60H (2)
Pain Link Frequency Relevance Heat
cytokine 6 97.28 Very High Very High Very High
psoriasis 4 84.36 Quite High
tolerance 6 69.80 Quite High
Central nervous system 28 21.60 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 39 99.20 Very High Very High Very High
Multiple Sclerosis 174 97.16 Very High Very High Very High
Psoriasis 4 84.36 Quite High
Autoimmune Disease 8 83.44 Quite High
Malignant Neoplastic Disease 4 74.44 Quite High
Leiomyosarcoma 59 60.88 Quite High
Disease 23 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Reprotox - General 1 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down-regulation of MHC expression, including the lmp2 gene, is one of the biological mechanisms that tumor cells use to evade host immune surveillance (Swann and Smyth, 2007).
Regulation (regulation) of lmp2 associated with cancer
1) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.55 Pain Relevance 0
Despite the scarcity of experimental evidences we might speculate that the cytokines responses towards MHC-I myelin epitopes (as demonstrated for the MHC-II [38]) is altered by gender, generating a scenario in which the influence of the LMP2 R60H polymorphism on specific myelin epitopes might impinges upon the MS onset only in females.
Regulation (influence) of LMP2 (R60H) associated with multiple sclerosis and cytokine
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.73 Pain Relevance 0.15
To investigate the impact of the LMP2 R60H polymorphism on the production of the epitope MBP111–119, we performed in vitro digestions of the substrate MBP102–129 by 20S immunoproteasomes (with or without PA28-??)
Spec (investigate) Regulation (impact) of LMP2 (R60H)
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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