INT280560

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.44
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB9) nucleoplasm (PSMB9) peptidase activity (PSMB9)
small molecule metabolic process (PSMB9) nucleus (PSMB9) cellular nitrogen compound metabolic process (PSMB9)
Anatomy Link Frequency
uterine 4
oligodendrocytes 2
PSMB9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 14 97.72 Very High Very High Very High
tolerance 3 82.84 Quite High
positron emission tomography 7 74.80 Quite High
Pain 7 68.24 Quite High
cytokine 3 52.12 Quite High
psoriasis 2 41.92 Quite Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leiomyosarcoma 413 99.28 Very High Very High Very High
Adenocarcinoma 14 99.04 Very High Very High Very High
Malignant Neoplastic Disease 28 98.40 Very High Very High Very High
Multiple Sclerosis 87 97.56 Very High Very High Very High
Uterine Fibroids 21 95.92 Very High Very High Very High
Cancer 234 93.24 High High
Disease 70 92.96 High High
Eosinophilia 14 71.32 Quite High
Hypercalcemia 14 70.68 Quite High
Pain 7 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
treatment markedly increased the expression of LMP2, a subunit of the proteasome, which alters the proteolytic specificity of proteasomes.
Positive_regulation (increased) of Gene_expression (expression) of LMP2
1) Confidence 0.64 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.66 Pain Relevance 0
Importantly, clinical studies have revealed loss of the ability to induce LMP2 expression in human uterine LMS tissues in comparison with normal USM tissues.
Positive_regulation (induce) of Gene_expression (expression) of LMP2 in uterine associated with leiomyosarcoma
2) Confidence 0.64 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 1.01 Pain Relevance 0
Furthermore, the experiments, performed separately at several medical facilities, revealed a serious loss in the ability to induce LMP2 expression in human uterine LMS tissues in comparison with normal USM tissues located in same tissue sections: normal total, 26 cases; LMA total, 24 cases; LMS total, 32 cases (Hayashi et al. 2006).
Positive_regulation (induce) of Gene_expression (expression) of LMP2 in uterine associated with leiomyosarcoma and uterine fibroids
3) Confidence 0.64 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.98 Pain Relevance 0
Furthermore, a recent report demonstrated the loss of ability to induce LMP2 expression, which is an interferon (IFN)-?
Positive_regulation (induce) of Gene_expression (expression) of LMP2
4) Confidence 0.64 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733082 Disease Relevance 0.98 Pain Relevance 0.10
-signal strongly induces LMP2 expression.
Positive_regulation (induces) of Gene_expression (expression) of LMP2
5) Confidence 0.64 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733082 Disease Relevance 1.00 Pain Relevance 0.11
In addition, immunohistochemistry showed marked LMP2 expression in cervical epithelial adenocarcinoma tissues as well as cell lines treated with IFN-?
Positive_regulation (marked) of Gene_expression (expression) of LMP2 associated with adenocarcinoma
6) Confidence 0.46 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.97 Pain Relevance 0
To investigate whether stable LMP2 expression contributes to cell growth phenotype in SKN cells, the experiment (using Affymetrix human GeneChip HG U133 Plus2.0) demonstrated the expression profile of SKN cells transfected with plasmid without insert (pCEP9) compared with LMP2 coding DNA (pCEP9-LMP2).
Spec (whether) Positive_regulation (stable) of Spec (whether) Gene_expression (expression) of LMP2
7) Confidence 0.46 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.27 Pain Relevance 0
In oligodendrocytes, a decreased presentation mediated by the LMP2 60HH variant of MBP epitopes (e.g.
Positive_regulation (mediated) of Gene_expression (variant) of LMP2 in oligodendrocytes
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.56 Pain Relevance 0.15

General Comments

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