INT280561

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 26 83.68 Quite High
cytokine 29 71.52 Quite High
Inflammation 21 50.00 Quite Low
Arthritis 48 5.00 Very Low Very Low Very Low
rheumatoid arthritis 22 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 95.36 Very High Very High Very High
Leiomyosarcoma 59 81.68 Quite High
INFLAMMATION 20 50.00 Quite Low
Malignant Neoplastic Disease 4 30.88 Quite Low
Arthritis 52 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 22 5.00 Very Low Very Low Very Low
Disease 19 5.00 Very Low Very Low Very Low
Immunization 9 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Hematological Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The growth of the original SKN cells, which had defective JAK1 activity, was unaffected by IFN-?
JAK1 Binding (activity) of
1) Confidence 0.26 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.39 Pain Relevance 0
These results suggest that for each JAK family member, CP-690,550 competes with ATP for binding to the active site of the kinase domain.
JAK Binding (binding) of
2) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.26

General Comments

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