INT280564

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.99
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB9) nucleoplasm (PSMB9) peptidase activity (PSMB9)
small molecule metabolic process (PSMB9) nucleus (PSMB9) cellular nitrogen compound metabolic process (PSMB9)
Anatomy Link Frequency
uterine 6
cortex 3
white matter 1
PSMB9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 28 96.40 Very High Very High Very High
metalloproteinase 4 74.84 Quite High
medulla 4 69.28 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 174 99.84 Very High Very High Very High
Leiomyosarcoma 236 99.44 Very High Very High Very High
Adenocarcinoma 8 99.04 Very High Very High Very High
Uterine Fibroids 12 96.20 Very High Very High Very High
Cancer 138 94.16 High High
Disease 50 89.08 High High
Targeted Disruption 8 83.84 Quite High
Eosinophilia 8 79.56 Quite High
Hypercalcemia 8 78.92 Quite High
Malignant Neoplastic Disease 16 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Defective LMP2 expression is likely to be a risk factor for the development of human uterine LMS, as it is in LMP2-deficient mice.


Negative_regulation (Defective) of Gene_expression (expression) of LMP2 in uterine associated with leiomyosarcoma
1) Confidence 0.54 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.80 Pain Relevance 0
Defective LMP2 expression may initiate the development of spontaneous human uterine LMS (Hayashi and Faustman, 2002; Hayashi et al. 2006).
Negative_regulation (Defective) of Gene_expression (expression) of LMP2 in uterine associated with leiomyosarcoma
2) Confidence 0.40 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 1.64 Pain Relevance 0.04
Importantly, clinical studies have revealed loss of the ability to induce LMP2 expression in human uterine LMS tissues in comparison with normal USM tissues.
Negative_regulation (loss) of Gene_expression (expression) of LMP2 in uterine associated with leiomyosarcoma
3) Confidence 0.40 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 1.02 Pain Relevance 0
In addition, immunohistochemistry showed marked LMP2 expression in cervical epithelial adenocarcinoma tissues as well as cell lines treated with IFN-?
Negative_regulation (showed) of Gene_expression (expression) of LMP2 associated with adenocarcinoma
4) Confidence 0.39 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.98 Pain Relevance 0
Moreover, LMP2 expression was predominant in MS plaques (Fig. 2A) compared to pre-plaque white matter and cortex while in the same CNS area of control only luminal endothelial cells were stained (Fig. 2B).
Negative_regulation (predominant) of Gene_expression (expression) of LMP2 in cortex associated with multiple sclerosis and central nervous system
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.78 Pain Relevance 0.18
Moreover, LMP2 expression was predominant in MS plaques (Fig. 2A) compared to pre-plaque white matter and cortex while in the same CNS area of control only luminal endothelial cells were stained (Fig. 2B).
Negative_regulation (predominant) of in white matter Gene_expression (expression) of LMP2 in cortex associated with multiple sclerosis and central nervous system
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

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