INT28057

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.25
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2c) plasma membrane (Adra2c) cytoplasm (Adra2c)
signal transducer activity (Adra2c)
Anatomy Link Frequency
central nervous system 1
neuromuscular junction 1
Adra2c (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 3 95.36 Very High Very High Very High
antinociception 1 94.32 High High
narcan 2 92.16 High High
Neurotransmitter 1 91.80 High High
gABA 1 89.20 High High
Pain threshold 1 82.52 Quite High
anesthesia 4 82.40 Quite High
Analgesic 3 75.00 Quite High
Antinociceptive 3 50.00 Quite Low
agonist 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 1 82.52 Quite High
Poisoning 1 81.84 Quite High
Bordatella Infection 1 81.72 Quite High
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three distinct alpha 2AR subtypes (alpha 2A, alpha 2B, alpha 2C) have been characterized by both pharmacological and molecular biological approaches; however, the lack of subtype-specific ligands has precluded an understanding of the physiological relevance of each subtype.
alpha 2C Binding (characterized) of
1) Confidence 0.36 Published 1998 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 9769701 Disease Relevance 0.08 Pain Relevance 0.05
The antinociceptive response could be dose dependently antagonized by opiate receptor and selective alpha2B-/alpha2C-receptor antagonists but not by a central nervous system-impermeant alpha2 antagonist (L659,066).
alpha2C Binding (antagonized) of in central nervous system
2) Confidence 0.36 Published 1999 Journal Anesthesiology Section Body Doc Link 9952154 Disease Relevance 0 Pain Relevance 0
Both of the perturbants inhibited [35S]TBPS binding at the same concentrations at which they reduced membrane order; however, the anesthetic was nearly 4 times more effective in reducing [35S]TBPS binding than was A2C.
A2C Binding (binding) of
3) Confidence 0.31 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2714367 Disease Relevance 0.08 Pain Relevance 0.34
Binding studies confirmed high affinity for the alpha 4 beta 2 nAChR subtype (Ki = 4.1 +/- 0.21 nM). nAChR functional activity studies on three different cell lines showed that 1a was devoid of any activity at the neuromuscular junction.
alpha 4 beta 2 nAChR subtype Binding (affinity) of in neuromuscular junction
4) Confidence 0.30 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9513595 Disease Relevance 0.08 Pain Relevance 0.37

General Comments

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