INT280583

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (ADRB1) plasma membrane (ADRB1) nucleus (ADRB1)
cytoplasm (ADRB1) signal transducer activity (ADRB1)
Anatomy Link Frequency
lung 2
ADRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 5 86.56 High High
Inflammation 12 82.60 Quite High
rheumatoid arthritis 2 66.40 Quite High
Arthritis 1 33.48 Quite Low
cytokine 3 5.20 Low Low
Kinase C 15 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 96.36 Very High Very High Very High
Asthma 6 94.88 High High
Disease 33 91.84 High High
Pulmonary Disease 2 85.84 High High
INFLAMMATION 15 82.60 Quite High
Rheumatoid Arthritis 3 66.56 Quite High
Hemorrhage 1 50.52 Quite High
Malaria 41 50.00 Quite Low
Experimental Arthritis 1 33.48 Quite Low
Cancer 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Determination of the standardized ADRB index
Negative_regulation (Determination) of Gene_expression (index) of ADRB
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0
Respirable As-ODNs (RASONs), as compared to systemically administered As-ODNs, offer the potential to selectively downregulate the AR-1 expression in the lung at much smaller doses and also minimize the risk of systemic side effects and toxicity.
Negative_regulation (downregulate) of Gene_expression (expression) of AR-1 in lung associated with toxicity
2) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.18 Pain Relevance 0.29

General Comments

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