INT280585

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.88
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 82.56 Quite High
tolerance 2 62.88 Quite High
Antihistamine 2 43.12 Quite Low
Kinase C 30 13.56 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
adenocard 10 5.00 Very Low Very Low Very Low
Bioavailability 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 54 99.84 Very High Very High Very High
Disease 66 85.80 High High
Apoptosis 10 77.32 Quite High
Non-small-cell Lung Cancer 8 74.92 Quite High
Reprotox - General 1 2 73.16 Quite High
Solid Tumor 8 72.08 Quite High
Ovarian Cancer 2 71.72 Quite High
Colon Cancer 4 71.08 Quite High
Hypersensitivity 8 68.72 Quite High
Thrombocytopenia 8 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preclinical studies of this drug have shown inhibition of tumour growth, more than 50% inhibition of raf-1 expression in tumour xenografts and increased sensitization of tumour cells to radiation and to chemotherapeutic agents [101, 102].
Negative_regulation (inhibition) of Gene_expression (expression) of raf-1 associated with cancer
1) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.18 Pain Relevance 0.11
ISIS 5132 was shown not only to decrease c-raf expression but also to increase tumour sensitivity [91].
Negative_regulation (decrease) of Gene_expression (expression) of c-raf associated with cancer
2) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.70 Pain Relevance 0

General Comments

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