INT280590

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
Anatomy Link Frequency
mononuclear cells 1
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 15 9.28 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 27 97.84 Very High Very High Very High
Disease 33 81.52 Quite High
Solid Tumor 4 74.48 Quite High
Apoptosis 5 73.04 Quite High
Adenocarcinoma 1 50.28 Quite High
Toxicity 7 41.80 Quite Low
Colon Cancer 2 40.32 Quite Low
Ovarian Cancer 1 38.80 Quite Low
Reprotox - General 1 1 36.00 Quite Low
Non-small-cell Lung Cancer 4 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a phase I trial, changes in the expression of c-raf1 mRNA were assessed in peripheral blood mononuclear cells, collected from patients with advanced cancers treated with ISIS 5132.
Transcription (expression) of c-raf in mononuclear cells associated with cancer
1) Confidence 0.52 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.75 Pain Relevance 0

General Comments

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