INT280595

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.06
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (RNASEH1) nucleus (RNASEH1) cytoplasm (RNASEH1)
RNASEH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 20 68.48 Quite High
Potency 5 67.68 Quite High
Kinase C 75 5.00 Very Low Very Low Very Low
Inflammation 60 5.00 Very Low Very Low Very Low
adenocard 25 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 35 55.88 Quite High
Disease 165 32.16 Quite Low
Sarcoma 5 9.32 Low Low
Avian Sarcoma 10 5.88 Low Low
Cancer 135 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 105 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 85 5.00 Very Low Very Low Very Low
INFLAMMATION 75 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 60 5.00 Very Low Very Low Very Low
Infection 55 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A most important mechanism employed by As-ODNs to cause the knockdown of proteins is the activation of RNAse H enzyme.
Positive_regulation (activation) of RNAse H
1) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0 Pain Relevance 0
Moreover, they are easy to synthesize, carry negative charges that ease their cell delivery, are capable of activating RNAse H and have suitable pharmacokinetics [7].
Positive_regulation (activating) of RNAse H
2) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0 Pain Relevance 0.07
As-ODNs, which are not able to activate RNAse H, produce their effects by targeting other steps of the mRNA synthesis.
Positive_regulation (activate) of RNAse H
3) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0 Pain Relevance 0
While phosphodiester and PS-ODNs can be recognized by RNAse H, the majority of other sugar or backbone modifications render the As-ODN incapable of activating RNAse H.
Positive_regulation (activating) of RNAse H
4) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0 Pain Relevance 0
However, third generation As-ODNs do not activate RNAse H and most likely produce their biological effects by causing steric hindrance of ribosomal machinery, resulting in translational arrest.
Neg (not) Positive_regulation (activate) of RNAse H
5) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.06 Pain Relevance 0

General Comments

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