INT280603

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.22
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myod1) nucleus (Myod1) enzyme binding (Myod1)
DNA binding (Myod1) transcription factor binding (Myod1) cytoplasm (Myod1)
Anatomy Link Frequency
muscle 1
skeletal muscle 1
heart 1
Myod1 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 24 97.24 Very High Very High Very High
withdrawal 1 90.12 High High
antagonist 17 83.92 Quite High
dexamethasone 6 79.24 Quite High
fibrosis 41 35.12 Quite Low
Potency 1 26.44 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiomyopathy 63 98.72 Very High Very High Very High
Muscular Dystrophy 141 96.84 Very High Very High Very High
Targeted Disruption 6 91.04 High High
Embryonal Carcinoma 23 89.08 High High
Stress 8 80.88 Quite High
Obesity 3 75.04 Quite High
Leukemia 1 69.60 Quite High
Birth Weight 9 63.44 Quite High
Insulin Resistance 20 50.00 Quite Low
Muscle Disease 5 39.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The equation describing MyoD mRNA (MyoDm) profile is:
Transcription (profile) of MyoD
1) Confidence 0.67 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.12
MyoD is basic-helix-loop-helix myogenic determination transcription factor that is not expressed in the heart but is expressed in all skeletal muscle committed cells.
Transcription (transcription) of myogenic determination in heart
2) Confidence 0.30 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.71 Pain Relevance 0
Myogenesis is largely regulated by the myogenic basic helix-loop-helix family of transcription factors (MyoD, myogenin, myf5, and MRF4) and myocyte enhancer factor 2, which regulate the expression of many muscle-specific genes, such as the myosin heavy chain (MHC) and creatine kinase (Lassar et al. 1994; Olson et al. 1995).
Transcription (transcription) of MyoD in muscle
3) Confidence 0.23 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.26 Pain Relevance 0.07
As shown in Figures 6C and 6D, treatment also induced the mRNA genes involved in skeletal muscle morphogenesis, myogenin mRNA (Fig. 6C) and MyoD mRNA (Fig. 6D).
Transcription (involved) of MyoD in skeletal muscle
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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