INT280621

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il6) cytoplasm (Irs1) signal transducer activity (Irs1)
cytosol (Irs1) extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
muscle 2
Il6 (Rattus norvegicus)
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 48 85.12 High High
Inflammation 6 84.20 Quite High
cytokine 6 82.96 Quite High
dexamethasone 10 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 40 90.56 High High
INFLAMMATION 6 84.20 Quite High
Obesity 2 64.40 Quite High
Diabetes Mellitus 10 56.20 Quite High
Exsanguination 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Metabolic Syndrome 4 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second phase was described by augmented inhibition of IRS-1 mRNA transcription by the IL-6 receptor.
IL-6 Negative_regulation (inhibition) of Transcription (transcription) of IRS-1 mRNA
1) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Thus it is reasonable to assume that increased expression of IL-6 receptor potentially enhances muscle sensitivity to IL-6 and augments the inhibitory effect of IL-6 on IRS-1 transcription.
IL-6 Negative_regulation (effect) of Transcription (transcription) of IRS-1 in muscle
2) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.40 Pain Relevance 0.19

General Comments

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