INT280647

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl) molecular_function (Mpl) cellular_component (Mpl)
biological_process (Mpl)
Mpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 94 46.96 Quite Low
dexamethasone 5 13.80 Low Low
tolerance 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 24 50.00 Quite Low
Diabetes Mellitus 9 5.00 Very Low Very Low Very Low
Exsanguination 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proposed PK/PD model reasonably captured the down-regulation of IRS-1 message by MPL administration (Fig. 8).
Gene_expression (administration) of MPL
1) Confidence 0.30 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Figure 4c shows the simulations of MPL kinetics, DR, and DR(N) during chronic infusion of MPL.
Gene_expression (kinetics) of MPL
2) Confidence 0.27 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0
The experiments were initiated by MPL dosing.
Gene_expression (dosing) of MPL
3) Confidence 0.27 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0

General Comments

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