INT280653

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl) molecular_function (Mpl) cellular_component (Mpl)
biological_process (Mpl)
Mpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 83 77.60 Quite High
tolerance 3 54.80 Quite High
dexamethasone 10 24.60 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 42 50.00 Quite Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Exsanguination 6 5.00 Very Low Very Low Very Low
Metabolic Syndrome 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stimulatory constant SC50_IL6R1m was estimated at 1.09 fmol/mg protein, suggesting high sensitivity to MPL action.
Positive_regulation (sensitivity) of MPL
1) Confidence 0.26 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
In the acute study, MyoD mRNA exhibits a sharp decline immediately following MPL treatment.
Positive_regulation (following) of MPL
2) Confidence 0.23 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
This was similar to the Class 1 genes suggesting a possible existence of a negative feedback regulator limiting the degree of increase of the message during chronic infusion of MPL.
Positive_regulation (increase) of MPL
3) Confidence 0.18 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.10

General Comments

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