INT280707

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.37
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cebpg) nucleus (Cebpg) DNA binding (Cebpg)
transcription factor binding (Cebpg)
Anatomy Link Frequency
muscles 1
eosinophil 1
Cebpg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 40 99.14 Very High Very High Very High
Inflammatory response 2 83.12 Quite High
Inflammation 39 67.52 Quite High
Nerve growth factor 18 53.80 Quite High
cytokine 28 10.80 Low Low
Neurotransmitter 5 9.28 Low Low
chemokine 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 11 99.32 Very High Very High Very High
INFLAMMATION 36 82.76 Quite High
Apoptosis 85 50.00 Quite Low
Neuroblastoma 3 48.24 Quite Low
Disease 21 47.52 Quite Low
Hypersensitivity 15 47.16 Quite Low
Stress 8 44.80 Quite Low
Cancer 5 37.92 Quite Low
Asthma 24 5.00 Very Low Very Low Very Low
Death 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has also been found that CS causes changes in gene as well as protein expression of transcription factors such as C/EBP-?
Gene_expression (expression) of C/EBP associated with corticosteroid
1) Confidence 0.75 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.13
In this regard, it remains to be determined whether MafK and Syn-1 gene expressions are altered by expressing the active or dominant-negative (or silencing) form of C/EBP and Ngn2 in PC (WT-Akt) and PC (DN-Akt) cells, respectively.
Gene_expression (expressing) of C/EBP
2) Confidence 0.65 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.03
B inhibition by HO-1/CO, other transcription factors, such as CCAAT/enhancer-binding protein (C/EBP) expression are decreased by HO-1/CO in LPS-treated RAW 264.7 cells [36] and activating protein (AP)-1 is also suppressed by hemin, an HO-1 inducer, in soleus muscles of Sprague-Dawley rats [39].
Gene_expression (expression) of C/EBP in muscles
3) Confidence 0.65 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.21 Pain Relevance 0.10
Forced expression of the transcription C/EBP members (CCAAT/enhancer-binding protein family) in progenitor cells induces myeloid and eosinophil differentiation.2 PU.1, an ETS transcription factor family member, is only expressed in hematopoietic cells.
Gene_expression (expression) of C/EBP in eosinophil
4) Confidence 0.58 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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