INT280708

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ass1) aging (Ass1) endoplasmic reticulum (Ass1)
nucleus (Ass1) ligase activity (Ass1) lysosome (Ass1)
Ass1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 91.48 High High
corticosteroid 35 76.28 Quite High
nMDA receptor 3 72.00 Quite High
Glutamate 24 70.04 Quite High
spastic colon 1 52.68 Quite High
rheumatoid arthritis 1 51.20 Quite High
Inflammation 4 46.08 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 63 95.84 Very High Very High Very High
Diabetes Mellitus 2 79.92 Quite High
Insulin Resistance 2 78.16 Quite High
Neurological Disease 3 75.84 Quite High
Stress 10 75.00 Quite High
Muscle Weakness 1 62.16 Quite High
Increased Venous Pressure Under Development 1 61.32 Quite High
Hypertension 1 59.60 Quite High
Functional Bowel Disorder 1 52.68 Quite High
Systemic Lupus Erythematosus 1 51.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urea synthesis alone requires five enzymes (arginosuccinate lyase, arginosuccinate synthetase, arginase, ornithine transcarbamoylase, and carbamoyl phosphate synthetase).
Positive_regulation (requires) of arginosuccinate synthetase
1) Confidence 0.41 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.61 Pain Relevance 0.15
The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric oxide production more effective and contributing to its toxic effects.
Positive_regulation (increased) of argininosuccinate synthetase associated with hypoxia
2) Confidence 0.10 Published 2010 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2880843 Disease Relevance 0.92 Pain Relevance 0.12

General Comments

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