INT280721

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl) molecular_function (Mpl) cellular_component (Mpl)
biological_process (Mpl)
Mpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 105 96.96 Very High Very High Very High
Glutamate 6 20.48 Low Low
tolerance 9 5.36 Low Low
spastic colon 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Exsanguination 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 3 5.00 Very Low Very Low Very Low
Organ Transplantation 3 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Muscle Weakness 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although most of the reports in the literature suggest an inhibitory effect of CS on OTC in fetal as well as in adult rats (Gautier et al. 1985; Gautier et al. 1977; Ulbright and Snodgrass, 1993), we observed a subtle and delayed up-regulation in this gene after both acute and chronic MPL.
Regulation (regulation) of MPL associated with corticosteroid
1) Confidence 0.18 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.16
Some genes that were simply up- or down-regulated after acute MPL showed complex biphasic patterns upon chronic infusion indicating involvement of secondary regulation.
Regulation (regulated) of MPL
2) Confidence 0.18 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.13
The dynamics of most of the genes showed more complex regulation during chronic infusion of MPL compared to acute bolus dosing.
Regulation (regulation) of MPL
3) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.05

General Comments

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