INT280771

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
AtT20 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 16 100.00 Very High Very High Very High
dexamethasone 9 99.76 Very High Very High Very High
amygdala 59 99.24 Very High Very High Very High
gABA 24 95.84 Very High Very High Very High
alcohol 11 81.76 Quite High
Kinase C 13 72.32 Quite High
addiction 8 67.56 Quite High
antagonist 2 57.84 Quite High
Neurotransmitter 6 52.72 Quite High
Hippocampus 3 6.00 Low Low
Disease Link Frequency Relevance Heat
Alcohol Addiction 8 73.64 Quite High
Anxiety Disorder 9 68.04 Quite High
Stress 30 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Adrenal Insufficiency 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to this latest paper, when steroid receptor coactivator 1a (SRC-1a) is over-expressed in AtT20 cells, the suppressive effect by dexamethasone on the Fsk-induced CRH gene promoter activity is enhanced, compared with the untransfected cells.
Positive_regulation (enhanced) of Positive_regulation (induced) of CRH gene in AtT20 associated with dexamethasone
1) Confidence 0.41 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.21
The ethanol- and CRF-induced increase in GABAergic transmission is mediated by CRF1 receptor activation, but the intracellular signaling mechanisms involved in this alteration in GABA transmission are still unknown.
Positive_regulation (mediated) of Positive_regulation (increase) of CRF-induced associated with gaba and gabaergic
2) Confidence 0.31 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.21 Pain Relevance 0.55

General Comments

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