INT280806

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Pomc) cytoplasm (Pomc) response to stress (Avpr1b)
signal transducer activity (Avpr1b) extracellular space (Pomc) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
corticotroph 2
Avpr1b (Rattus norvegicus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 28 99.62 Very High Very High Very High
Aggression 1 45.48 Quite Low
Emergencies 1 35.36 Quite Low
Shock 1 34.68 Quite Low
Hypertension 1 32.04 Quite Low
Pressure Volume 2 Under Development 2 14.08 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Almost all CRH-positive neurons do not express vasopressin in the basal condition; however, a number of these neurons start to express vasopressin after receiving the stress, resulting in the increase of the ACTH secretion via the corticotroph V1b receptor (V1bR), as is the case with CRH.
V1bR Positive_regulation (increase) of Localization (secretion) of ACTH in corticotroph associated with stress
1) Confidence 0.19 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.17 Pain Relevance 0

General Comments

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