INT280808

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkcg, Fos) cytosol (Prkcg) plasma membrane (Prkcg)
intracellular (Prkcg) DNA binding (Fos) transcription factor binding (Fos)
Prkcg (Rattus norvegicus)
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 12 100.00 Very High Very High Very High
cytokine 13 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 60.96 Quite High
Stress 28 46.52 Quite Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Adrenal Insufficiency 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the SRE element is an important region of the PKC-induced transcription of the c-fos gene, mediated by the activation of the ERK signaling cascade.
PKC Positive_regulation (induced) of Transcription (transcription) of fos associated with kinase c
1) Confidence 0.02 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.33

General Comments

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