INT28083

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.23
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM)
cytoplasm (VIM)
Anatomy Link Frequency
stroma 2
filaments 2
Section 3 2
fibroblast 2
VIM (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 99.62 Very High Very High Very High
interstitial cystitis 8 95.82 Very High Very High Very High
Enkephalin 2 89.80 High High
opiate 2 84.00 Quite High
agonist 1 83.44 Quite High
metalloproteinase 14 73.04 Quite High
chemokine 1 59.52 Quite High
Neuropeptide 1 48.64 Quite Low
narcan 1 25.00 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 203 99.84 Very High Very High Very High
Renal Cancer 36 99.68 Very High Very High Very High
Breast Cancer 136 99.16 Very High Very High Very High
Cancer 308 98.54 Very High Very High Very High
Adhesions 56 98.08 Very High Very High Very High
Candida Infection 1 96.56 Very High Very High Very High
Interstitial Cystitis 8 95.82 Very High Very High Very High
Clear Cell Sarcoma 28 84.84 Quite High
Rhabdomyosarcoma 2 81.88 Quite High
Bone Cancer 8 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed decrease in CDH1 (E-cadherin) in CC (p-value = 0.0045) also matched previously published reports, as did the decrease in VIM (vimentin) expression in Chr RCCa [13,16].
Negative_regulation (decrease) of Gene_expression (expression) of VIM associated with renal cancer and carcinoma
1) Confidence 0.41 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.29 Pain Relevance 0
The observed decrease in CDH1 (E-cadherin) in CC (p-value = 0.0045) also matched previously published reports, as did the decrease in VIM (vimentin) expression in Chr RCCa [13,16].
Negative_regulation (decrease) of Gene_expression (expression) of vimentin associated with renal cancer and carcinoma
2) Confidence 0.35 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.29 Pain Relevance 0
The three opioid peptides markedly reduced the expression of vimentin filaments, the phagocytic activity, and the display of HLA-DR molecules at concentrations of 10(-6), 10(-8), and 10(-10) M.
Negative_regulation (reduced) of Gene_expression (expression) of vimentin in filaments associated with opioid
3) Confidence 0.30 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2717883 Disease Relevance 0.10 Pain Relevance 0.53
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Negative_regulation (decreased) of Gene_expression (expression) of vimentin associated with interstitial cystitis
4) Confidence 0.25 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.57 Pain Relevance 0.57
Immunohistochemical findings on day 7 and 28 showed that the expression of type I collagen, type IV collagen, laminin, and vimentin were strongly positive in the transplanted gelatin hydrogels of the precursor/gelatin group while they were faint in the gelatin and fibroblast/gelatin groups.
Negative_regulation (positive) of Gene_expression (expression) of vimentin in fibroblast
5) Confidence 0.13 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0
The primary tumor was 1.5 cm3 and although large, did not appear to invade the stroma and lacked vimentin expression.
Negative_regulation (lacked) of Neg (lacked) Gene_expression (expression) of vimentin in stroma associated with cancer
6) Confidence 0.12 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.91 Pain Relevance 0
The primary lesion lacked vimentin expression and the cell line was shown to be cytokeratin positive which is consistent with basal type invasive carcinoma.
Negative_regulation (lacked) of Neg (lacked) Gene_expression (expression) of vimentin associated with carcinoma
7) Confidence 0.12 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 1.04 Pain Relevance 0
Genistein also decreased the levels of vimentin, a protein that is typically associated with a mesenchymal, or invasive, state (see Section 3.2).
Negative_regulation (decreased) of Gene_expression (levels) of vimentin in Section 3
8) Confidence 0.07 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.58 Pain Relevance 0.07
Lack of vimentin expression was also an unexpected finding.
Negative_regulation (Lack) of Gene_expression (expression) of vimentin
9) Confidence 0.06 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.45 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox