INT28084

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 49
Total Number 49
Disease Relevance 35.12
Pain Relevance 5.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM)
cytoplasm (VIM)
Anatomy Link Frequency
smooth muscle 3
muscle 3
neuronal 2
spindle cells 2
histiocyte 1
VIM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 144 99.80 Very High Very High Very High
Opioid 3 99.54 Very High Very High Very High
narcan 1 99.42 Very High Very High Very High
Thalamus 4 99.12 Very High Very High Very High
Inflammation 68 98.32 Very High Very High Very High
Chronic pancreatitis 22 97.60 Very High Very High Very High
Pain 20 97.12 Very High Very High Very High
interstitial cystitis 8 93.28 High High
anesthesia 1 93.20 High High
tetrodotoxin 1 91.16 High High
Disease Link Frequency Relevance Heat
Cancer 593 99.90 Very High Very High Very High
Carcinoma 145 99.84 Very High Very High Very High
Clear Cell Sarcoma 20 99.84 Very High Very High Very High
Rheumatoid Arthritis 145 99.80 Very High Very High Very High
Cyst 12 99.62 Very High Very High Very High
Renal Cancer 31 99.60 Very High Very High Very High
Lipoma 2 99.60 Very High Very High Very High
Necrosis 29 99.28 Very High Very High Very High
Pancreatic Cancer 96 99.04 Very High Very High Very High
Disease 115 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VIM was also found to be increased in CC with a p-value = 0.0045, which was consistent with the literature.
Positive_regulation (increased) of VIM associated with carcinoma
1) Confidence 0.67 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.28 Pain Relevance 0
The sites receiving the greatest attention are portions of Vc, Vim, Vop, and the medial thalamus.
Positive_regulation (portions) of Vim in thalamus associated with thalamus
2) Confidence 0.50 Published 1995 Journal Neurosurg. Clin. N. Am. Section Abstract Doc Link 7696876 Disease Relevance 0.20 Pain Relevance 0.26
Immunohistochemically, both components were positive for cytokeratin and epithelial membrane antigen, but negative for vimentin and desmin.
Positive_regulation (negative) of vimentin
3) Confidence 0.48 Published 2000 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 10982621 Disease Relevance 0.94 Pain Relevance 0.10
Histologically, our cases had inflammatory myofibroblastic tumors very similar to that of other sites; the spindle cells were positive for vimentin and muscle-specific actin.
Positive_regulation (positive) of vimentin in muscle associated with inflammation and cancer
4) Confidence 0.48 Published 2006 Journal Arch Iran Med Section Abstract Doc Link 16859068 Disease Relevance 1.17 Pain Relevance 0.38
Although the mechanism of induction of autoantibodies against vimentin still remains obscure, proteolysis of the intact, native protein may play a role in development of autoimmunity.
Positive_regulation (induction) of vimentin associated with autoimmune disease
5) Confidence 0.48 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.87 Pain Relevance 0
The tumors cells showed a positive reactivity for placental alkaline phosphatase and for vimentin.
Positive_regulation (reactivity) of vimentin associated with cancer
6) Confidence 0.47 Published 2002 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 11937977 Disease Relevance 0.59 Pain Relevance 0.16
In addition, these cells were immunoreactive to glial acidic fibrillary protein, growth-associated protein (GAP-43), and vimentin, further suggesting that dental pulp contains a population of cells with membrane properties similar to neuronal satellite cells.
Positive_regulation (immunoreactive) of vimentin in neuronal
7) Confidence 0.45 Published 1994 Journal Arch. Oral Biol. Section Abstract Doc Link 7945020 Disease Relevance 0 Pain Relevance 0.13
The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.
Positive_regulation (positive) of VIM in spindle cells
8) Confidence 0.45 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.85 Pain Relevance 0.21
On histopathological examination, the tumor consisted of interlacing bundles of smooth muscle cells, which were positive for vimentin, desmin, and a-actin.
Positive_regulation (positive) of vimentin in smooth muscle cells associated with cancer
9) Confidence 0.45 Published 2005 Journal Hinyokika Kiyo Section Abstract Doc Link 16285627 Disease Relevance 0.88 Pain Relevance 0.09
For example, although increased levels of vimentin antibodies were found in pancreatic cancer, as compared to chronic pancreatitis and healthy individuals, the relationship between tumor burden, tumor staging and antibody levels needs further clarification.
Positive_regulation (increased) of vimentin associated with cancer, pancreatic cancer and chronic pancreatitis
10) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.26 Pain Relevance 0.10
Immunohistochemical staining showed tumor cells with positive results for vimentin and CD68.
Positive_regulation (results) of vimentin associated with cancer
11) Confidence 0.44 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.85 Pain Relevance 0.07
The cytoplasm of some of the atypical endothelial cells was immunohistochemically positive for vimentin, factor VIII-related antigen, CD 34, and thrombomodulin.
Positive_regulation (positive) of vimentin in endothelial cells
12) Confidence 0.44 Published 1998 Journal Brain Tumor Pathol Section Abstract Doc Link 10328547 Disease Relevance 0.39 Pain Relevance 0.08
Immunohistochemical staining was positive for vimentin, neuronal-specific enolase and PGP9.5.
Positive_regulation (positive) of vimentin in neuronal
13) Confidence 0.44 Published 2000 Journal Dig Surg Section Abstract Doc Link 11053953 Disease Relevance 0.70 Pain Relevance 0.09
Immunostains showed the tumor cells to be diffusely positive for vimentin and smooth muscle actin and to be focally positive for calponin.
Positive_regulation (positive) of vimentin in smooth muscle associated with cancer
14) Confidence 0.43 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14987133 Disease Relevance 0.92 Pain Relevance 0.09
At immunohistochemical phenotypification, the tumor was positive for vimentin, cytokeratins and epithelial membrane antigen (EMA), as well as for some other multidirectional antibodies, including a membranous reaction for CD99.
Positive_regulation (positive) of vimentin associated with cancer
15) Confidence 0.41 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10886744 Disease Relevance 0.70 Pain Relevance 0
Immunoperoxidase testing was positive for CD10 and vimentin and negative for gross cystic disease fluid protein (GCDFP), S-100, HMB-45, muscle-specific antigen, and desmin, supporting the diagnosis of metastatic RCC (Figure 3).
Positive_regulation (positive) of vimentin in muscle associated with renal cell carcinoma and disease
16) Confidence 0.40 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566576 Disease Relevance 0.79 Pain Relevance 0
Stain for cytokeratin was negative while tumor cells were positive for vimentin.
Positive_regulation (positive) of vimentin associated with cancer
17) Confidence 0.40 Published 2006 Journal BMC Urol Section Body Doc Link PMC1513593 Disease Relevance 0.66 Pain Relevance 0.10
Stain for cytokeratin is negative while tumor cells are positive for vimentin in clear cell sarcoma of the kidney.
Positive_regulation (positive) of vimentin in kidney associated with cancer and clear cell sarcoma
18) Confidence 0.40 Published 2006 Journal BMC Urol Section Body Doc Link PMC1513593 Disease Relevance 1.48 Pain Relevance 0.04
Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.
Positive_regulation (positive) of vimentin in globules associated with rhinitis and cancer
19) Confidence 0.39 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.87 Pain Relevance 0.08
The number of degranulated mast cells in the ultrastructural picture and the number of pancreatic stellate cells stained positive for vimentin and alpha-smooth muscle actin were counted.
Positive_regulation (positive) of vimentin in mast cells
20) Confidence 0.37 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12143220 Disease Relevance 0.17 Pain Relevance 0

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