INT280841

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Jun) response to stress (Crh) cytoplasm (Crh)
cytosol (Jun) extracellular space (Crh) extracellular region (Crh)
Anatomy Link Frequency
neurons 2
Jun (Mus musculus)
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 12 73.00 Quite High
cytokine 13 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 84.00 Quite High
Hypoglycemia 2 77.28 Quite High
Stress 28 9.16 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with vasopressin, the Fos/Jun family proteins are rapidly expressed in the CRH neurons in response to a variety of extracellular stimuli, suggesting that AP1 proteins activate the CRH gene expression.
AP1 Positive_regulation (activate) of Gene_expression (expression) of CRH gene in neurons
1) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

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