INT28088

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 11.06
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) enzyme binding (Alb) DNA binding (Alb)
protein complex (Alb) response to stress (Alb) cytoplasm (Alb)
Anatomy Link Frequency
plasma 6
liver 2
Erythrocytes 1
brain 1
skeletal muscle 1
Alb (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 9 100.00 Very High Very High Very High
Nerve growth factor 4 100.00 Very High Very High Very High
tetrodotoxin 3 99.88 Very High Very High Very High
depression 24 99.76 Very High Very High Very High
Morphine 7 99.64 Very High Very High Very High
Opioid 2 99.64 Very High Very High Very High
sSRI 21 98.96 Very High Very High Very High
Osteoarthritis 108 98.84 Very High Very High Very High
fluoxetine 28 98.00 Very High Very High Very High
imagery 249 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Disease 148 99.96 Very High Very High Very High
Depression 28 99.76 Very High Very High Very High
Diabetic Retinopathy 5 99.52 Very High Very High Very High
Osteoarthritis 86 98.84 Very High Very High Very High
Cancer 342 98.32 Very High Very High Very High
Necrosis 27 98.08 Very High Very High Very High
Hypercalcemia 59 97.82 Very High Very High Very High
Obesity 107 97.80 Very High Very High Very High
Infection 45 97.24 Very High Very High Very High
Diabetes Mellitus 110 96.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Buspirone is mainly bound to albumin and alpha 1-acid glycoprotein.
albumin Binding (bound) of
1) Confidence 0.47 Published 1988 Journal Pharmacotherapy Section Abstract Doc Link 3041384 Disease Relevance 0.68 Pain Relevance 0.36
Diabetic patients were divided into 2 groups according to the following diagnostic criteria: 1) nephropathy cases, i.e., patients with diabetic retinopathy and overt nephropathy, indicated by a urinary albumin excretion rate (AER) ?
albumin Binding (indicated) of associated with diabetes mellitus, renal disease and diabetic retinopathy
2) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 0.97 Pain Relevance 0
Clenbuterol (5 mg/kg) increased the percentage of plasma free (non-albumin bound) tryptophan, plasma free fatty acid concentration and the concentration of tryptophan and 5-hydroxyindoleacetic acid (5-HIAA) in the brain.
albumin Binding (bound) of in plasma
3) Confidence 0.35 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6225031 Disease Relevance 0.19 Pain Relevance 0.28
Fluoxetine, a novel selective serotonin reuptake inhibitor utilized in the treatment of depression, is avidly bound to serum albumin and alpha-1-acid glycoprotein (AAG).
albumin Binding (bound) of associated with depression, ssri and fluoxetine
4) Confidence 0.31 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9443847 Disease Relevance 0.52 Pain Relevance 0.48
Tetrodonic acid, a relatively non-toxic derivative of tetrodotoxin, was conjugated with bovine serum albumin and injected i.p. to BALB/c mice.
albumin Binding (conjugated) of associated with tetrodotoxin
5) Confidence 0.28 Published 1989 Journal Toxicon Section Abstract Doc Link 2718194 Disease Relevance 0.08 Pain Relevance 0.25
Evans Blue dye (8 mg/kg in PBS, Wako Pure Chemical Industries, Ltd., Osaka, Japan), which binds to plasma albumin, was used to stain the vasculature.
albumin Binding (binds) of in plasma
6) Confidence 0.27 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018094 Disease Relevance 0 Pain Relevance 0.10
We studied physical development, behavioral characteristics, and learning capacity in the offspring of mice immunized with nerve growth factor and bovine serum albumin.
serum albumin Binding (immunized) of in nerve associated with nerve growth factor
7) Confidence 0.24 Published 2004 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 15514732 Disease Relevance 0 Pain Relevance 0.19
Gf interacts with hydrophobic proteins of the extracellular matrix such as collagen, proteoglycans, decorin and tenascin, and it is largely bound to serum albumin after i.v. administration [18].
albumin Binding (bound) of in extracellular matrix
8) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.22 Pain Relevance 0.18
The intensity of in vivo staining for formaldehyde-treated serum albumin, which is a specific ligand for SECs, was reduced from 2 to 12 hours.
albumin Binding (ligand) of in SECs
9) Confidence 0.21 Published 2003 Journal Microcirculation Section Body Doc Link 14557822 Disease Relevance 0 Pain Relevance 0
High binding affinity to plasma albumin and extracellular matrix proteins may explain the delayed initial CNS tissue accumulation but also the persisting presence of Gf within the brain parenchyma for up to 10 days [9,18].
plasma albumin Binding (affinity) of in brain associated with central nervous system
10) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.50 Pain Relevance 0.31
In the circulation, Gf is largely bound to albumin [18].
albumin Binding (bound) of
11) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.55 Pain Relevance 0.29
In humans, the maximum plasma concentration is reached 6-12 h after dosing, shows good tissue distribution, dose proportionality at the range 25-100 mg, and is highly bound to albumin (95%).
albumin Binding (bound) of in plasma
12) Confidence 0.13 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.56 Pain Relevance 0.12
It has contraceptive activity [12], exerts anti-androgenic effects [13] and binds to serum proteins such as corticosteroid-binding globulin (CBG) and albumin [14].
albumin Binding (binds) of associated with corticosteroid
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.11 Pain Relevance 0.24
Next is from the aspect of the interaction between the complexes with the serum proteins such as albumin, albeit low in the lung, might increase the tendency of the DNA release and eventually reduced the interaction between the intact DNA with target cells [31].

3.4.

albumin Spec (might) Binding (interaction) of in lung
14) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
The albumin concentration was determined colorimetrically at 628 nm based on albumin binding to bromcresol green, using an albumin BCG diagnostic kit (Sigma Chemical Co., St.
albumin Binding (binding) of
15) Confidence 0.12 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 0.15 Pain Relevance 0.15
The effect of PDGF and VEGF receptor inhibitors on tumor vessel leakiness was determined by injection of Evans blue, a dye that quantitatively binds to albumin in the circulation.
albumin Binding (binds) of associated with cancer
16) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781164 Disease Relevance 1.13 Pain Relevance 0
The diagnosis of hypercalcemia is based on concentration of ionized calcium, because the serum calcium level may be erroneously low due to binding of circulating calcium to albumin.
albumin Binding (binding) of associated with hypercalcemia
17) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.39 Pain Relevance 0.10
BSA: bovine serum albumin; FBS: fetal bovine serum; HG: high gainer; IFN: interferon; IL: interleukin; LG: low gainer; NOx: nitrate and nitrite; S-GAG: sulfated glycosaminoglycan; TNF: tumor necrosis factor.


serum albumin Binding (nitrite) of associated with necrosis and cancer
18) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 1.02 Pain Relevance 0.31
A C6-hemisuccinate derivative of morphine was prepared and conjugated to bovine serum albumin and ovalbumin.
serum albumin Binding (conjugated) of associated with morphine
19) Confidence 0.08 Published 2002 Journal Hybrid. Hybridomics Section Abstract Doc Link 12165146 Disease Relevance 0.09 Pain Relevance 0.25
In addition to these two models, Xie et al. and Gong et al. also generated Alb- and Fatty Acid-Binding Protein (FABP)-activated hSXR (VP-hSXR) mice in which constitutively activated hSXR were expressed in the liver (Alb promoter driven) or in the liver and intestine (FABP promoter driven), respectively [Gong et al., 2006; Xie et al., 2000a] .
Alb Binding (generated) of in intestine
20) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

General Comments

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