INT280889

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 3.45
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox10) nucleus (Sox10) DNA binding (Sox10)
transcription factor binding (Sox10) cytoplasm (Sox10)
Anatomy Link Frequency
sensory neurons 2
nociceptor 2
neuronal 1
neural crest 1
cap cells 1
Sox10 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 144 97.84 Very High Very High Very High
dorsal root ganglion 432 97.24 Very High Very High Very High
Spinal cord 108 82.20 Quite High
Peripheral nervous system 18 55.88 Quite High
ketamine 26 49.52 Quite Low
Inflammation 4 15.44 Low Low
Calcitonin gene-related peptide 18 9.44 Low Low
Nerve growth factor 90 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 120 99.52 Very High Very High Very High
Repression 4 98.52 Very High Very High Very High
Ganglion Cysts 432 97.24 Very High Very High Very High
Nociception 162 96.60 Very High Very High Very High
Cancer 656 87.84 High High
Body Weight 36 82.52 Quite High
Injury 40 74.48 Quite High
Neurological Disease 36 55.04 Quite High
Carcinoma 56 50.00 Quite Low
Metastasis 8 43.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EYFP/Runx1 expression in DOX-treated neurospheres gradually declined in intensity and disappeared after 2–3 weeks in culture which is in agreement with the cessation of Sox10 expression (data not shown).
Gene_expression (expression) of Sox10
1) Confidence 0.72 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0
It also gave us the possibility to mimic the normal cellular development pattern, in which the expression of the transcription factor Sox10 precedes that of Runx1, a temporal sequence which seems to be crucial for the guiding the differentiation of bNCSCs toward nociceptive-type sensory neurons.


Gene_expression (expression) of Sox10 in sensory neurons associated with nociception
2) Confidence 0.72 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.16 Pain Relevance 0.08
This finding suggests that the decision of neural progenitors to become neuronal or glial is regulated by other transcription factors in bNCSCs when they still express Sox10.
Gene_expression (express) of Sox10 in neuronal
3) Confidence 0.72 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.18
Sox10+/rtTA neurospheres were transfected with the TREbi-Runx1-EYFP expression vector (Fig. 1D).
Gene_expression (transfected) of Sox10
4) Confidence 0.62 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.08 Pain Relevance 0
In an additional experiment to evaluate transplant size and overall survival of transplanted bNCSCs, CAG-EGFP:Sox10+/rtTA bNCSCs ubiquitously expressing EGFP were used (n = 6 treated; n = 3 control) with the same treatment.
Gene_expression (bNCSCs) of Sox10
5) Confidence 0.62 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.33 Pain Relevance 0.06
For bromodeoxyuridine (BrdU) labeling, six mice with neurospheres harboring Sox10+/rtTA:TREbi-EYFP-Runx1 transgenes were injected with BrdU intraperitoneally once every day (10 mg/ml; 200 ?
Gene_expression (rtTA) of Sox10
6) Confidence 0.62 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.12 Pain Relevance 0.03
This approach allowed us to use Sox10-rtTA mice [23] to specifically target Sox10-expressing cells, since only they will respond with TRE-Runx1 activation.
Gene_expression (expressing) of Sox10
7) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.19 Pain Relevance 0.06
The mechanism for this might be due to the specific targeting of Sox10-expressing cells for Runx1 overexpression.
Gene_expression (expressing) of Sox10
8) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.06 Pain Relevance 0.13
The latter appeared exclusively in Sox10-expressing cells that were transfected with an inducible Runx1 construct and treated with DOX.
Gene_expression (expressing) of Sox10
9) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.05 Pain Relevance 0.25
Consistent with previous results [20], immunohistochemical analysis showed that Sox10 was expressed in E11 DRGs of Sox10+/rtTA mice (Fig. 1B).
Gene_expression (expressed) of Sox10
10) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.06 Pain Relevance 0
Sox10 or SRY-box containing gene 10, is a high mobility group transcription factor expressed in all neural crest (NC) cells and is involved in several aspects of NC development [17, 18].
Gene_expression (expressed) of Sox10 in neural crest
11) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.15 Pain Relevance 0.12
Sox10 expression was also found in newly formed bNCSC neurospheres (Fig. 1C) and the expression with regards to passage and days in culture was assayed by RT-PCR (supporting information Fig. 1).
Gene_expression (expression) of Sox10
12) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.07 Pain Relevance 0
Here, we explore whether conditionally induced expression of the key transcription factor Runx1 in Sox10-expressing cells from transgenic mice can guide the differentiation of such peripherally transplanted bNCSCs toward a nociceptor neuron phenotype.
Gene_expression (expressing) of Sox10 in nociceptor associated with targeted disruption and nociceptor
13) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.37 Pain Relevance 0.26
Furthermore, it was shown that the DRG itself does not significantly contribute to neurosphere formation and that the bNCSCs (as well as the actual boundary cap cells in vivo) express Krox20, Sox10, and the multipotency marker SSEA-1, which is not the case for surrounding cell types [12, 13].
Gene_expression (express) of Sox10 in cap cells associated with dorsal root ganglion
14) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.30 Pain Relevance 0.24
Here, we explore whether conditionally induced expression of the key transcription factor Runx1 in Sox10-expressing cells from transgenic mice can guide the differentiation of such peripherally transplanted bNCSCs toward a nociceptor neuron phenotype.
Gene_expression (-) of Sox10 in nociceptor associated with targeted disruption and nociceptor
15) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.37 Pain Relevance 0.26
We find that exogenous activation of Runx1 expression in Sox10 expressing bNCSCs promotes survival and induces specific differentiation toward nonpeptidergic nociceptive-type sensory neurons in vitro and after transplantation.


Gene_expression (expressing) of Sox10 in sensory neurons associated with nociception
16) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.21 Pain Relevance 0.06
We induced the expression of the key transcription factor Runx1 in Sox10-expressing bNCSCs.
Gene_expression (expressing) of Sox10
17) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733376 Disease Relevance 0.23 Pain Relevance 0.05
The surprising function of Sox10 in the regulation of EMT/MET in G-2 CCS as well as the transcriptional targets of Sox10 remains to be elucidated.
Gene_expression (function) of Sox10
18) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.06 Pain Relevance 0
The surprising function of Sox10 in the regulation of EMT/MET in G-2 CCS as well as the transcriptional targets of Sox10 remains to be elucidated.
Gene_expression (targets) of Sox10
19) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.05 Pain Relevance 0
As seen by RT-PCR Sox10 was initially highly expressed, but this expression declined after 4 to 5 weeks in culture.
Gene_expression (expressed) of Sox10
20) Confidence 0.48 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.09 Pain Relevance 0

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