INT280891

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox10) nucleus (Sox10) DNA binding (Sox10)
transcription factor binding (Sox10) cytoplasm (Sox10)
Anatomy Link Frequency
sensory neurons 1
neural crest cell 1
Sox10 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 8 79.44 Quite High
Spinal cord 6 46.80 Quite Low
dorsal root ganglion 24 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 9 95.04 Very High Very High Very High
Cancer 164 67.64 Quite High
Metastasis 2 52.84 Quite High
Carcinoma 14 50.00 Quite Low
Ganglion Cysts 24 5.00 Very Low Very Low Very Low
Targeted Disruption 16 5.00 Very Low Very Low Very Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also gave us the possibility to mimic the normal cellular development pattern, in which the expression of the transcription factor Sox10 precedes that of Runx1, a temporal sequence which seems to be crucial for the guiding the differentiation of bNCSCs toward nociceptive-type sensory neurons.


Transcription (transcription) of Sox10 in sensory neurons associated with nociception
1) Confidence 0.64 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.16 Pain Relevance 0.08
As a notable component of the G-2 GRN we identified the transcription factor Sox10, known as a glial and neural crest cell fate regulator [76], and demonstrated that perturbation in the expression of a single component of the GRN can significantly influence the composition of the CCS.
Transcription (transcription) of Sox10 in neural crest cell
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.12 Pain Relevance 0

General Comments

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