INT280906

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.26
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
leukocytes 2
blood 1
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 29 93.88 High High
fibrosis 2 80.56 Quite High
Inflammatory response 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 38 99.04 Very High Very High Very High
Injury 115 98.68 Very High Very High Very High
Colon Cancer 52 98.20 Very High Very High Very High
INFLAMMATION 32 93.88 High High
Cancer 52 92.12 High High
Fibrosis 2 80.56 Quite High
Wound Healing 11 70.16 Quite High
Adhesions 9 62.80 Quite High
Recurrence 2 40.92 Quite Low
Death 2 37.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression, and leading to an overall reduction in Cd45+ leukocytes within the diabetic wound tissue.
Negative_regulation (reduction) of Cd45 in leukocytes associated with diabetes mellitus and injury
1) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.08 Pain Relevance 0.16
This study showed that combining negative (CD45 depletion) and positive (CTC enrichment with BerEP4 beads) immunomagnetic selection successively yields a high amount of CTC (1 CTC/1 ml blood).
Negative_regulation (depletion) of CD45 in blood
2) Confidence 0.05 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2868015 Disease Relevance 0.61 Pain Relevance 0
Moreover, negative enrichment with CD45 depletion of leucocytes may lead to a theoretical "loss" of CTC as they could stick together with the leucocytes-beads complexes.
Negative_regulation (depletion) of CD45 in leucocytes
3) Confidence 0.05 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2868015 Disease Relevance 0.56 Pain Relevance 0

General Comments

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