INT280914

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.99
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
granulation 4
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 58 91.28 High High
chemokine 23 91.12 High High
Inflammatory response 6 77.40 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 41 99.68 Very High Very High Very High
Injury 230 95.24 Very High Very High Very High
Diabetes Mellitus 76 94.96 High High
INFLAMMATION 64 91.28 High High
Carcinoma 25 88.96 High High
Colon Cancer 25 86.76 High High
Bordatella Infection 3 84.64 Quite High
Breast Cancer 4 78.72 Quite High
Apoptosis 46 63.20 Quite High
Metastasis 25 45.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of adhesion coincides with increased levels of secreted CXCL12 over that same time span, from not detectable at day 0 to a maximum after 4-days in culture (data not shown).
Positive_regulation (increased) of Localization (secreted) of CXCL12 associated with adhesions
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.10 Pain Relevance 0.08
However, direct application of SDF-1/CXCL12 enhances mobilization of EPCs and improves healing, specifically enhancing recruitment of Cd34+ EPCs into the neovasculature of granulation tissue [39, 42].
Positive_regulation (enhances) of Localization (application) of CXCL12 in granulation
2) Confidence 0.32 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.44 Pain Relevance 0.19
However, direct application of SDF-1/CXCL12 enhances mobilization of EPCs and improves healing, specifically enhancing recruitment of Cd34+ EPCs into the neovasculature of granulation tissue [39, 42].
Positive_regulation (enhancing) of Localization (application) of CXCL12 in granulation
3) Confidence 0.32 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.45 Pain Relevance 0.19

General Comments

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