INT280918

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.88
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Epc1) nucleus (Epc1)
Anatomy Link Frequency
macrophages 1
Epc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 87 99.00 Very High Very High Very High
fibrosis 6 89.76 High High
Inflammatory response 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 345 99.68 Very High Very High Very High
INFLAMMATION 96 99.00 Very High Very High Very High
Diabetes Mellitus 114 94.80 High High
Fibrosis 6 89.76 High High
Adhesions 9 72.00 Quite High
Cytomegalovirus Infection 42 66.48 Quite High
Wound Healing 33 51.60 Quite High
Obesity 3 28.32 Quite Low
Repression 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activity resulted in improved repair and healing due to inactivation of macrophages [40], and our present results show that in addition to improving EPC recruitment, HOXA3 also attenuates the TNF pathway, reducing inflammation.
EPC Binding (recruitment) of in macrophages associated with inflammation
1) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.20 Pain Relevance 0.17
Because HOXA3 strongly stimulates neovascularization in the wound [3], we also investigated whether EPC recruitment to the wound was influenced.
EPC Spec (whether) Binding (recruitment) of associated with injury
2) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.25 Pain Relevance 0.03
This study indicates that the ability of HOXA3 to activate multiple linked pathways to improve angiogenesis and EPC recruitment, as well as suppressing inflammatory pathways that can inhibit repair and regeneration, comprises a truly successful therapy for diabetic chronic wounds.
EPC Binding (recruitment) of associated with inflammation, diabetes mellitus and injury
3) Confidence 0.03 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.44 Pain Relevance 0.05

General Comments

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