INT280925

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Context Info
Confidence 0.53
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.91
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Prom1) plasma membrane (Prom1) cilium (Prom1)
Anatomy Link Frequency
blood 1
brain 1
NSCs 1
Prom1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 29 68.32 Quite High
imagery 32 50.00 Quite Low
Central nervous system 16 5.00 Very Low Very Low Very Low
neurotrophin 3 16 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 96 99.98 Very High Very High Very High
Cytomegalovirus Infection 126 99.66 Very High Very High Very High
Viral Infection 26 99.42 Very High Very High Very High
Neurodegenerative Disease 12 91.76 High High
Cancer 84 89.92 High High
Injury 119 85.80 High High
INFLAMMATION 32 68.32 Quite High
Sensorineural Hearing Loss 2 65.28 Quite High
Cerebral Palsy 2 64.00 Quite High
Intellectual Impairment 6 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease of the CD133 expression levels in vivo might provide an explanation for the apparently smaller difference in CD133 expression in vivo compared to in vitro.
Negative_regulation (decrease) of CD133
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.29 Pain Relevance 0
MCMV brain infection reduces CD133(+) cell number and alters nestin expression
Negative_regulation (reduces) of CD133 in brain associated with cytomegalovirus infection and infection
2) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.05 Pain Relevance 0
In addition, viral infection was demonstrated to cause a loss of NSCs expressing CD133 and nestin.
Negative_regulation (loss) of CD133 in NSCs associated with viral infection
3) Confidence 0.23 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.79 Pain Relevance 0
Flow cytometry was performed to analyze cleared peripheral blood samples using GFP, Cd34, and Cd133 as markers of EPCs at the following time points: day 0, day 4, day 7, and day 14.
Negative_regulation (using) of Cd133 in blood
4) Confidence 0.20 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.78 Pain Relevance 0.03

General Comments

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