INT280933

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.53
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst) nucleus (Fst) cytoplasm (Fst)
Anatomy Link Frequency
myotube 2
brain 1
Fst (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 227 99.24 Very High Very High Very High
antagonist 24 93.84 High High
cINOD 78 92.64 High High
Central nervous system 63 90.48 High High
cytokine 60 83.96 Quite High
Hippocampus 105 81.60 Quite High
Inflammatory response 30 68.96 Quite High
fibrosis 3 59.68 Quite High
Intracerebroventricular 12 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 269 99.24 Very High Very High Very High
Neurodegenerative Disease 384 96.76 Very High Very High Very High
Gliosis 69 73.76 Quite High
Cancer 95 69.56 Quite High
Frailty 43 65.12 Quite High
Fibrosis 3 59.68 Quite High
Aging 8 57.92 Quite High
Muscular Atrophy 26 54.96 Quite High
Body Weight 12 50.80 Quite High
Necrosis 9 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While PD restores myotube size and MyHC content by blocking ERK without affecting Akt activity, the opposite occurs in follistatin-hyperexpressing cultures, wherein ERK activation remains comparable to non-transfected TNF?
follistatin Binding (occurs) of in myotube
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.18 Pain Relevance 0.03
No reduction in size or MyHC content occurs in follistatin-overexpressing myotubes treated with TNF?
follistatin Binding (occurs) of in myotubes
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.23 Pain Relevance 0.03
FS-288 binds to activin A and therefore blocks the activin A that is expressed in the brain from having any effect.
FS-288 Binding (binds) of in brain
3) Confidence 0.08 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.80 Pain Relevance 0.48
Therefore, since FS-288 binds to activin A and thereby inhibits activin A, we reasoned that the inhibition of neurogenesis by FS-288 may result from inhibition of the anti-inflammatory effects of activin A.
FS-288 Binding (binds) of associated with inflammation and neurodegenerative disease
4) Confidence 0.08 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.27 Pain Relevance 0.67
This raises the possibility that FS-288 in our study may mediate some of its effects through binding other BMP and TGF?
FS-288 Binding (binding) of
5) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.05 Pain Relevance 0.42

General Comments

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