INT28094

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Context Info
Confidence 0.37
First Reported 1989
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 13.57
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 10
osteoblasts 3
bone tissue 2
hip 1
skeleton 1
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 17 100.00 Very High Very High Very High
headache 11 100.00 Very High Very High Very High
Dismenorea 1 99.78 Very High Very High Very High
spinal inflammation 9 98.62 Very High Very High Very High
metalloproteinase 58 96.00 Very High Very High Very High
cytokine 36 94.08 High High
Kinase C 6 93.96 High High
rheumatoid arthritis 17 93.20 High High
Inflammation 21 91.48 High High
Osteoarthritis 15 87.52 High High
Disease Link Frequency Relevance Heat
Osteoporosis 360 100.00 Very High Very High Very High
Diabetes Mellitus 21 100.00 Very High Very High Very High
Headache 9 100.00 Very High Very High Very High
Metastasis 8 100.00 Very High Very High Very High
Postmenopausal Osteoporosis 66 99.92 Very High Very High Very High
Dysmenorrhea 1 99.78 Very High Very High Very High
Cancer 28 99.56 Very High Very High Very High
Malignant Neoplastic Disease 6 99.44 Very High Very High Very High
Rhabdomyosarcoma 4 99.40 Very High Very High Very High
Necrosis 7 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that physical activity associated with BCT had an interactive effect on vitamin D and PTH levels, as others have described complex relationships between physical activity, vitamin D status, PTH levels, and bone health [18,19].
PTH Binding (interactive) of
1) Confidence 0.37 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0 Pain Relevance 0
At the hip, PTH-AL was associated with a much larger increase in BMD than PTH-control (p < 0.001).
PTH-AL Binding (associated) of in hip
2) Confidence 0.37 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.09 Pain Relevance 0
Alendronate concurrently with PTH
PTH Binding (Alendronate) of
3) Confidence 0.37 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.53 Pain Relevance 0
In children, hypercalcemia secondary to rhabdomyosarcoma is not uncommon and has been associated with bony metastasis, increased parathyroid hormone, and increased levels of prostaglandin E2.
parathyroid hormone Binding (associated) of in parathyroid associated with rhabdomyosarcoma, hypercalcemia and metastasis
4) Confidence 0.36 Published 1989 Journal Arch. Intern. Med. Section Abstract Doc Link 2719511 Disease Relevance 1.14 Pain Relevance 0.08
Osteoclastic activation is the ultimate way of bone resorption in neoplasia, induced by the combined effects of tumor-secreted humoral factors (especially parathyroid hormone-related peptides) and osteoclastic-osteoblastic interaction.
parathyroid hormone Binding (interaction) of in parathyroid associated with cancer, hypercalcemia and osteoporosis
5) Confidence 0.36 Published 2003 Journal Tumori Section Abstract Doc Link 12908775 Disease Relevance 1.22 Pain Relevance 0.06
Those with a positive association will be adjusted for potentially confounding covariates such as gender, age, weight, serum calcium, diabetes, and intact serum PTH.
PTH Binding (association) of associated with diabetes mellitus
6) Confidence 0.36 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2936367 Disease Relevance 0.35 Pain Relevance 0
Recombinant human parathyroid hormone (PTH) stimulates bone formation, in contrast to antiresorptive agents.
parathyroid hormone Binding (Recombinant) of in parathyroid
7) Confidence 0.36 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.26 Pain Relevance 0
Also, studies find the increases in bone formation induced by antisclerostin antibody, unlike PTH, are not associated with increases in bone resorption in the aged rodent skeleton.
PTH Binding (associated) of in skeleton associated with hypercalcemia
8) Confidence 0.33 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.40 Pain Relevance 0
The binding of the molecule to the PTH receptor-1 activates adenylate cyclase and several phospholipases (A, C, D) and increases intracellular cAMP and calcium levels.
PTH Binding (binding) of
9) Confidence 0.33 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.31 Pain Relevance 0
Parathyroid hormone (PTH) has been recognized as an anabolic agent in bone tissue for over 70 years (Selye 1932) but, until recently, its catabolic activity in maintaining plasma calcium homeostasis received most attention.
Parathyroid hormone Binding (recognized) of in bone tissue
10) Confidence 0.33 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.59 Pain Relevance 0.04
Parathyroid hormone (PTH) has been recognized as an anabolic agent in bone tissue for over 70 years (Selye 1932) but, until recently, its catabolic activity in maintaining plasma calcium homeostasis received most attention.
PTH Binding (recognized) of in bone tissue
11) Confidence 0.33 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.59 Pain Relevance 0.04
A two-factor ANOVA with repeated measures was used to test for main effects of both ethnicity and time, as well as ethnicity-by-time interactions in 25(OH)D and PTH.
PTH Binding (interactions) of
12) Confidence 0.31 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0 Pain Relevance 0
The intermittent pulses of parathyroid hormone bind to the parathyroid hormone-1 receptor, a G-protein-coupled protein, which leads to subsequent activation of cyclic AMP-dependent protein kinase A and protein kinase C signalling pathways, both of which play key roles in regulating osteoblastogenesis and osteoblast function.19
parathyroid hormone Binding (bind) of in osteoblast associated with kinase c and osteoporosis
13) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.34 Pain Relevance 0.05
Intermittent pulses of parathyroid hormone activate different mechanisms to those activated by continuous administration of parathyroid hormone, and thus accounts for the different effects on bone metabolism.18
parathyroid hormone Binding (administration) of in parathyroid
14) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.32 Pain Relevance 0.04
The Cox regression was adjusted for age, gender, HD age, calcium and PTH.
PTH Binding (gender) of
15) Confidence 0.27 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.20 Pain Relevance 0
Under normal conditions concentrations of calcium are highly modulated by the interplay between parat hormone (PTH), calcitonin and vitamin D.
PTH Binding (interplay) of
16) Confidence 0.25 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475608 Disease Relevance 0.43 Pain Relevance 0
The peptide binds to the PTH receptor and increases both calcium levels (through bony resorption and calcium reabsorption in the kidney) and the production of pro-inflammotory cytokines, stimulating IL-6 from osteoblasts and IL-8 and TNF-a from non-bony tissue such as normal immune cells[6].
PTH Binding (binds) of in osteoblasts associated with cytokine
17) Confidence 0.24 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.64 Pain Relevance 0.12
PTH in combination with other antiresorptive agents
PTH Binding (combination) of
18) Confidence 0.22 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.08 Pain Relevance 0
Recombinant human parathyroid hormone (PTH) stimulates bone formation, in contrast to antiresorptive agents.
PTH Binding (Recombinant) of in parathyroid
19) Confidence 0.22 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.26 Pain Relevance 0
At the completion of the urine collection, participants had blood drawn for calcium, phosphorus, parathyroid hormone (PTH), parathyroid related protein (PTH-rP), 1,25-(OH)2 vitamin D, albumin, bone specific alkaline phosphatase, estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH).
PTH Binding (drawn) of in urine
20) Confidence 0.17 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.44 Pain Relevance 0

General Comments

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