INT280942

Context Info Confidence 0.22 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.13 Pain Relevance 0.91

extracellular region (Fst) nucleus (Fst) cytoplasm (Fst)

Fst (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 75 99.84 depression 15 99.60 antidepressant 10 83.20 Inflammatory response 10 81.68 Central nervous system 21 81.40 fibrosis 1 73.72 withdrawal 1 65.12 cINOD 26 57.16 monoamine 5 53.68 antagonist 8 44.40

Disease Link Frequency Relevance Heat Depressive Disorder 2 99.88 INFLAMMATION 89 99.84 Depression 19 99.60 Stress 3 93.80 Hepatocellular Cancer 1 85.88 Neurodegenerative Disease 128 75.76 Fibrosis 1 73.72 Disease 7 67.68 Sprains And Strains 47 56.32 Cognitive Disorder 1 52.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While no animal model can fully recapitulate the range of symptoms associated with depressive disorders, the relevance of the TST and FST to human depression has been extensively documented.

Localization (relevance) of FST associated with depression and depressive disorder

1) Confidence 0.22 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.78 Pain Relevance 0.36

The peripheral actions of activin A and follistatin on inflammation are clearly complex and unraveling this will require a broad understanding of TGF?

Localization (actions) of follistatin associated with inflammation

2) Confidence 0.18 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.35 Pain Relevance 0.55

General Comments

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