INT280947

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.73
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Acvr1) kinase activity (Acvr1)
Anatomy Link Frequency
embryos 1
microglia 1
Acvr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 162 96.12 Very High Very High Very High
Intracerebroventricular 8 80.80 Quite High
Hippocampus 70 5.00 Very Low Very Low Very Low
cINOD 58 5.00 Very Low Very Low Very Low
Central nervous system 45 5.00 Very Low Very Low Very Low
cytokine 28 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 3 98.12 Very High Very High Very High
INFLAMMATION 190 96.12 Very High Very High Very High
Heterotopic Ossification 261 95.76 Very High Very High Very High
Targeted Disruption 36 89.12 High High
Congenital Anomalies 12 85.60 High High
Fibrodysplasia Ossificans Progressiva 51 76.40 Quite High
Neurodegenerative Disease 256 50.00 Quite Low
Injury 65 5.00 Very Low Very Low Very Low
Gliosis 46 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their data indicate that low levels of caAlk2 expression are sufficient to transduce a sufficient amount of BMP signaling to compromise normal development of embryos.
Gene_expression (expression) of caAlk2 in embryos
1) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.74 Pain Relevance 0
We speculate that conditionally activating the caAlk2 expression with late tissue-specific Cre in future studies might generate a mouse model that is useful for study of HO.

2.2.

Gene_expression (expression) of caAlk2 associated with heterotopic ossification
2) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.87 Pain Relevance 0
Fukuda et al. reported using a Cre-loxP system to conditionally express a constitutively active ALK2 receptor (caALK2) to activate BMP signaling, but this produced embryonic lethality [29].
Gene_expression (express) of caALK2 associated with embryonic lethality
3) Confidence 0.31 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.74 Pain Relevance 0
, expressed the type II receptor, ActRIIb (Fig. 6A), and the type I receptor Alk2 (ActRI) (Fig. 6B).
Gene_expression (expressed) of Alk2
4) Confidence 0.11 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.19 Pain Relevance 0.13
+ microglia expressed the (A) type II receptor, ActRIIb, and the (B) type I receptor, Alk2, on the cell surface.
Gene_expression (expressed) of Alk2 in microglia
5) Confidence 0.05 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.18 Pain Relevance 0.13

General Comments

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