INT280948

Context Info Confidence 0.17 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.29 Pain Relevance 0.18

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)

Anatomy Link Frequency stem cells 1 Dcx (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 35 92.52 antagonist 8 68.96 Inflammation 75 66.28 Central nervous system 21 29.32 Inflammatory response 10 18.32 cINOD 26 5.00 cytokine 14 5.00 Intracerebroventricular 4 5.00 Pyramidal cell 2 5.00 Spinal cord 1 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 128 98.88 Injury 10 87.60 INFLAMMATION 89 66.28 Gliosis 23 5.00 Disease 7 5.00 Hypertrophy 4 5.00 Death 4 5.00 Necrosis 3 5.00 Cancer 3 5.00 Convulsion 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased number of neurons resulted from changes in proliferation of Sox2-positive neural stem cells [21] and nestin-positive precursor cells [22], an effect that led to increased numbers of Dcx expressing neuroblasts and neurogenesis.

Negative_regulation (numbers) of Dcx in stem cells associated with neurodegenerative disease

1) Confidence 0.17 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.29 Pain Relevance 0.18

General Comments

This test has worked.