INT280949

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.51
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst, Inhbe) nucleus (Fst) cytoplasm (Fst)
Anatomy Link Frequency
brain 1
Fst (Mus musculus)
Inhbe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 150 99.24 Very High Very High Very High
Central nervous system 42 90.48 High High
cINOD 52 83.96 Quite High
cytokine 28 83.96 Quite High
Hippocampus 70 81.60 Quite High
Inflammatory response 20 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Intracerebroventricular 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 178 99.24 Very High Very High Very High
Neurodegenerative Disease 256 97.20 Very High Very High Very High
Gliosis 46 67.80 Quite High
Dilated Cardiomyopathy 10 66.68 Quite High
Muscular Dystrophy 34 66.32 Quite High
Necrosis 6 48.72 Quite Low
Cancer 8 48.36 Quite Low
Disease Progression 4 35.20 Quite Low
Aging 2 32.96 Quite Low
Heart Disease 2 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FS-288 binds to activin A and therefore blocks the activin A that is expressed in the brain from having any effect.
FS-288 Binding (binds) of activin in brain
1) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.81 Pain Relevance 0.48
Therefore, since FS-288 binds to activin A and thereby inhibits activin A, we reasoned that the inhibition of neurogenesis by FS-288 may result from inhibition of the anti-inflammatory effects of activin A.
FS-288 Binding (binds) of activin associated with inflammation and neurodegenerative disease
2) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.33 Pain Relevance 0.67
For example, follistatin and follistatin like related gene (FLRG) bind to activin in addition to myostatin and GDF associated serum protein 1 (GASP1) also contains protease domains [16]–[19].
follistatin Binding (bind) of activin
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.19 Pain Relevance 0
For example, follistatin and follistatin like related gene (FLRG) bind to activin in addition to myostatin and GDF associated serum protein 1 (GASP1) also contains protease domains [16]–[19].
follistatin Binding (bind) of activin
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.19 Pain Relevance 0

General Comments

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