INT280951

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.09
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr4, S100a8) cytoplasm (Tlr4, S100a8) extracellular space (S100a8)
signal transduction (Tlr4) extracellular region (S100a8) cytoskeleton (S100a8)
Anatomy Link Frequency
neuronal 2
Tlr4 (Mus musculus)
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 75 100.00 Very High Very High Very High
cytokine 14 99.96 Very High Very High Very High
Central nervous system 21 98.58 Very High Very High Very High
Hippocampus 35 98.24 Very High Very High Very High
Inflammatory stimuli 1 82.60 Quite High
cINOD 26 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 89 100.00 Very High Very High Very High
Death 4 96.52 Very High Very High Very High
Stroke 2 95.44 Very High Very High Very High
Neurodegenerative Disease 128 94.88 High High
Gliosis 23 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The injection of LPS into the CNS can be used to model these inflammatory effects because LPS activates TLR4 to induce microglial activation and the release of pro-inflammatory cytokines, stimulating inflammation in the hippocampus, without inducing any neuronal death [30].
TLR4 Positive_regulation (induce) of Localization (release) of pro-inflammatory in neuronal associated with inflammation, hippocampus, central nervous system, death and cytokine
1) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.09 Pain Relevance 0.69

General Comments

This test has worked.

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