INT281033

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.96
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 58 98.40 Very High Very High Very High
Chronic pancreatitis 2 77.92 Quite High
Potency 6 73.68 Quite High
palliative 2 10.16 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
bradykinin 9 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 98 99.60 Very High Very High Very High
Dyspepsia 58 98.40 Very High Very High Very High
Hepatitis B Virus Infection 57 94.36 High High
Hereditary Angioedema 123 91.80 High High
Cancer 74 90.60 High High
Adenocarcinoma 4 79.52 Quite High
Pancreatitis 6 77.92 Quite High
Metastasis 6 75.08 Quite High
Syndrome 20 69.92 Quite High
Hepatitis C Virus Infection 42 69.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further confirmed the expression levels of two up-regulated proteins (MBL2 and MLCK2) in the sera from pancreatic cancer patients using western blot analysis.
Regulation (regulated) of MBL2 associated with pancreatic cancer
1) Confidence 0.34 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 1.55 Pain Relevance 0.08
Up-regulation of serum MBL2 and MLCK2 in pancreatic cancer was found by the DIGE and the 3 D spot images were shown in Figure 2.
Regulation (regulation) of MBL2 associated with pancreatic cancer
2) Confidence 0.34 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.65 Pain Relevance 0
To further evaluate the effect of TLR2 and MBL2 polymorphisms on the susceptibility of FD, we investigated the prevalence of both TLR2 and MBL genotypes in H. pylori positive and negative subjects respectively (TableĀ 3).
Regulation (effect) of MBL2 associated with nud
3) Confidence 0.18 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 1.12 Pain Relevance 0.35
In consequence, the activation observed depended on MBL/MASP-2 complex concentration and arrangement (oligomerization, MASP content), reflecting the fact that the potential ability of the serum to initiate the MBL pathway did not correlate with C1-INH activity in patients.
Regulation (depended) of MBL
4) Confidence 0.06 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.22 Pain Relevance 0.04
Median serum MBL concentrations, MBL pathway activity, symptom scores, and C4 levels between the various groups were compared with the Mann-Whitney U-test (rank test) because of the lack of a normal distribution.
Regulation (concentrations) of MBL
5) Confidence 0.03 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.71 Pain Relevance 0.03
Median serum MBL concentrations, MBL pathway activity, symptom scores, and C4 levels between the various groups were compared with the Mann-Whitney U-test (rank test) because of the lack of a normal distribution.
Regulation (concentrations) of MBL
6) Confidence 0.03 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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