INT281077

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.35
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2, Gria3) plasma membrane (Gria2, Gria3) protein complex (Gria2, Gria3)
endoplasmic reticulum (Gria2)
Anatomy Link Frequency
neuronal 1
Gria2 (Mus musculus)
Gria3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 36 98.80 Very High Very High Very High
Central nervous system 17 97.68 Very High Very High Very High
long-term potentiation 56 93.80 High High
nMDA receptor 32 88.20 High High
Hippocampus 17 85.92 High High
IPN 23 85.36 High High
Anterior cingulate cortex 82 78.64 Quite High
agonist 2 77.76 Quite High
Neuropathic pain 9 73.92 Quite High
central sensitization 18 66.48 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 23 85.36 High High
Hyperalgesia 13 76.00 Quite High
Neuropathic Pain 9 73.92 Quite High
Nociception 59 52.76 Quite High
Injury 9 48.40 Quite Low
Depression 5 17.16 Low Low
Pain 40 5.00 Very Low Very Low Very Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low
Hypersensitivity 13 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GluA2/GluA3 receptors may play a complementary role in the constitutive delivery pathway via GluA2-mediated interaction with N-ethylmaleimide-sensitive fusion protein (NSF) and class II PDZ domain proteins [50].
GluA2 Binding (interaction) of GluA3
1) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.60
The role of Non-PDZ domain-containing protein, such as N-ethylmaleimide sensitive fusion (NSF) protein (an ATPase), in neuronal membrane fusion processes and regulatory interaction with GluR2 and GluR3 subunits of AMPA receptors has been investigated.
AMPA Binding (receptors) of GluR3 in neuronal
2) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.29 Pain Relevance 0.28
AMPA receptors are heteromeric molecules comprising various combinations of GluR1, GluR2, GluR3, and GluR4 subunits.
AMPA Binding (combinations) of GluR3
3) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.05 Pain Relevance 0.31

General Comments

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