INT281084

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca, Mapk1) protein complex (Prkaca, Mapk1) cytoplasm (Prkaca, Mapk1)
nucleus (Prkaca, Mapk1) kinase activity (Prkaca, Mapk1) nucleoplasm (Mapk1)
Prkaca (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 316 97.04 Very High Very High Very High
long-term potentiation 301 96.60 Very High Very High Very High
Hippocampus 15 92.56 High High
nMDA receptor 57 73.40 Quite High
Calcium channel 1 68.76 Quite High
Glutamate 7 66.40 Quite High
Neurotransmitter 3 66.00 Quite High
Pain 16 46.24 Quite Low
Lasting pain 14 37.08 Quite Low
Neuropathic pain 1 32.60 Quite Low
Disease Link Frequency Relevance Heat
Pain 30 46.24 Quite Low
Neuropathic Pain 1 32.60 Quite Low
INFLAMMATION 8 31.76 Quite Low
Targeted Disruption 144 29.76 Quite Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the downstream target of AC1, cAMP-dependent protein kinase (PKA) may activate MEK and ERK/MAPK.
PKA Positive_regulation (activate) of ERK
1) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.62
As the downstream target of AC1, cyclic-AMP (cAMP)-dependent protein kinase (PKA) is known to activate extracellular signal-regulated kinase (ERK) and ERK/MAPK (mitogen-activated protein kinase).
PKA Positive_regulation (activate) of ERK
2) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.48
As the downstream target of AC1, cyclic-AMP (cAMP)-dependent protein kinase (PKA) is known to activate extracellular signal-regulated kinase (ERK) and ERK/MAPK (mitogen-activated protein kinase).
PKA Positive_regulation (activate) of ERK
3) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.48
As the downstream target of AC1, cyclic-AMP (cAMP)-dependent protein kinase (PKA) is known to activate extracellular signal-regulated kinase (ERK) and ERK/MAPK (mitogen-activated protein kinase).
PKA Positive_regulation (activate) of extracellular signal-regulated kinase
4) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.48

General Comments

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