INT281085

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2, Nsf) plasma membrane (Gria2, Nsf) vesicle-mediated transport (Nsf)
endoplasmic reticulum (Gria2) ATPase activity (Nsf) protein complex (Gria2)
Gria2 (Mus musculus)
Nsf (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 5 97.00 Very High Very High Very High
long-term potentiation 54 94.04 High High
nMDA receptor 28 88.44 High High
Hippocampus 10 88.24 High High
central sensitization 9 86.56 High High
Spinal cord 10 84.24 Quite High
Anterior cingulate cortex 82 81.52 Quite High
IPN 14 77.36 Quite High
nociceptor 3 28.96 Quite Low
Spinal sensitization 1 15.32 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 8 98.04 Very High Very High Very High
Neuropathic Pain 5 97.00 Very High Very High Very High
Inflammatory Pain 14 77.36 Quite High
Injury 7 52.56 Quite High
Nociception 33 5.00 Very Low Very Low Very Low
Pain 32 5.00 Very Low Very Low Very Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Hypersensitivity 11 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GluA2/GluA3 receptors may play a complementary role in the constitutive delivery pathway via GluA2-mediated interaction with N-ethylmaleimide-sensitive fusion protein (NSF) and class II PDZ domain proteins [50].
GluA2 Binding (interaction) of NSF
1) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.05 Pain Relevance 0.61
Garry et al. reported that cell-permeable blocking peptides targeting for interactions of GluR2 with NSF or for GluR2/3-GRIP/PICK1 complex may have anti-hyperalgesic effects in a neuropathic pain model [13].
GluR2 Binding (interactions) of NSF associated with hyperalgesia and neuropathic pain
2) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.35 Pain Relevance 0.34

General Comments

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