INT281128

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd4, Cxcr4) endosome (Cxcr4) cell adhesion (Cd4)
cytoplasmic membrane-bounded vesicle (Cxcr4) enzyme binding (Cd4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
peripheral nerve 1
Cd4 (Rattus norvegicus)
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 42 92.48 High High
Inflammation 2 87.36 High High
chemokine 52 79.72 Quite High
cytokine 3 73.20 Quite High
Inflammatory response 2 68.80 Quite High
Thermal hyperalgesia 3 45.80 Quite Low
Neuropathic pain 12 44.24 Quite Low
Sciatic nerve 6 39.76 Quite Low
Demyelination 2 38.92 Quite Low
Fibrositis 1 37.40 Quite Low
Disease Link Frequency Relevance Heat
Injury 33 95.64 Very High Very High Very High
Ganglion Cysts 42 92.48 High High
INFLAMMATION 4 87.36 High High
Nociception 7 79.28 Quite High
Neuropathic Pain 16 76.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 50.00 Quite Low
Hyperalgesia 5 45.80 Quite Low
Rheumatoid Arthritis 10 45.52 Quite Low
Demyelinating Disease 3 38.92 Quite Low
Sleep Disorders 1 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased functional signaling of MCP1/CCR2 may be due to an indirect mechanism by which CXCR4 receptors located on Schwann cells in the peripheral nerve are activated by the gp120/hCD4.
hCD4 Positive_regulation (activated) of CXCR4 in peripheral nerve
1) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.71 Pain Relevance 0.37

General Comments

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