INT281142

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr3) extracellular space (Ccr3) plasma membrane (Ccr3)
signal transducer activity (Ccr3)
Anatomy Link Frequency
Th1 cells 1
Ccr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 80 100.00 Very High Very High Very High
imagery 6 95.44 Very High Very High Very High
qutenza 7 89.92 High High
dorsal root ganglion 42 83.36 Quite High
Intracerebroventricular 1 68.08 Quite High
nociceptor 5 59.56 Quite High
ischemia 3 59.44 Quite High
Inflammation 19 50.00 Quite Low
antagonist 27 29.20 Quite Low
Neuropathic pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Graft Vs Host Disease 1 88.84 High High
Ganglion Cysts 42 83.36 Quite High
Injury 42 82.20 Quite High
Cv General 4 Under Development 1 66.68 Quite High
Cv Unclassified Under Development 3 59.44 Quite High
INFLAMMATION 22 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 50.00 Quite Low
Renal Disease 2 47.68 Quite Low
Rheumatoid Arthritis 10 10.80 Low Low
Neuropathic Pain 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and lymphotactin, as well as the chemokine receptors CCR2 and CCR5, in the absence of upregulation of CCR3 and CCR8, which are Th2 chemokine receptor phenotypes [19]. vMIP-II inhibited the firm arrest and transmigration of Th1 cells under in vitro flow conditions and exerted an agonistic action on CCR3 driving a Th2 immune response [16].
Positive_regulation (upregulation) of CCR3 in Th1 cells associated with chemokine
1) Confidence 0.46 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.50 Pain Relevance 0.25
IP-10, the ligand for the CXCR3 chemokine receptor, was not upregulated in this animal model (data not shown).
Neg (not) Positive_regulation (upregulated) of CXCR3 chemokine receptor associated with chemokine
2) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.24 Pain Relevance 0.60

General Comments

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