INT281144

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.38
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
nerve 3
spinal cord 2
cell body 1
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 60 100.00 Very High Very High Very High
Eae 86 99.88 Very High Very High Very High
Spinal cord 110 99.74 Very High Very High Very High
Neuropathic pain 81 99.72 Very High Very High Very High
dorsal root ganglion 42 99.56 Very High Very High Very High
Demyelination 11 98.40 Very High Very High Very High
withdrawal 36 96.40 Very High Very High Very High
Hyperalgesia 54 95.04 Very High Very High Very High
antagonist 87 91.20 High High
Thermal hyperalgesia 21 88.40 High High
Disease Link Frequency Relevance Heat
Injury 117 99.88 Very High Very High Very High
Neuropathic Pain 148 99.72 Very High Very High Very High
Ganglion Cysts 42 99.56 Very High Very High Very High
Nociception 37 99.24 Very High Very High Very High
Demyelinating Disease 12 98.40 Very High Very High Very High
Hyperalgesia 83 95.04 Very High Very High Very High
Nervous System Injury 26 70.32 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 50.00 Quite Low
Hypersensitivity 10 11.12 Low Low
Aggression 3 8.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanical- and electrical-evoked nociceptive input to the spinal cord in CCI rats involves CCR2 signalling
Regulation (involves) of Gene_expression (signalling) of CCR2 in spinal cord associated with nociception, eae and spinal cord
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.82 Pain Relevance 0.81
CCR2 expression in sensory cells could support either a peripheral or a central site of action of CCR2 in analgesia depending on the particular location of the receptor (nerve, cell body or axon terminals in the spinal cord).
Regulation (depending) of Gene_expression (expression) of CCR2 in nerve associated with spinal cord and analgesia
2) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.57 Pain Relevance 1.15
Injury induced alteration of CCR2 mRNA and protein expression in lumbar DRG
Regulation (alteration) of Gene_expression (expression) of CCR2 mRNA associated with dorsal root ganglion and injury
3) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.41 Pain Relevance 0.18
CCR2 expression in sensory cells could support either a peripheral or a central site of action of CCR2 in analgesia depending on the particular location of the receptor (nerve, cell body or axon terminals in the spinal cord).
Regulation (depending) of in cell body Gene_expression (expression) of CCR2 in nerve associated with spinal cord and analgesia
4) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.57 Pain Relevance 1.15

General Comments

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