INT281155

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ITIH4, Ddc) lyase activity (Ddc) extracellular region (ITIH4)
intracellular (Ddc) plasma membrane (ITIH4) cellular amino acid metabolic process (Ddc)
ITIH4 (Homo sapiens)
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 24 98.56 Very High Very High Very High
chemokine 104 97.92 Very High Very High Very High
dorsal root ganglion 84 91.88 High High
Eae 4 85.04 High High
antagonist 36 57.84 Quite High
imagery 12 57.56 Quite High
qutenza 14 24.08 Low Low
withdrawal 24 23.04 Low Low
Sciatic nerve 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 42 99.58 Very High Very High Very High
Neuropathic Pain 32 98.56 Very High Very High Very High
Nociception 14 96.64 Very High Very High Very High
Ganglion Cysts 84 91.88 High High
Injury 66 91.00 High High
Hypersensitivity 8 89.80 High High
Rheumatoid Arthritis 20 71.72 Quite High
Disease 4 66.08 Quite High
Demyelinating Disease 6 40.32 Quite Low
Aids-related Complex 2 7.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this previous study was informative in beginning to understand the mechanisms underlying this type of neuropathic pain, we wished to observe the degree to which the HIV1 viral coat protein, gp120 interacts with ddC and if this changes the drug associated pattern of chemokine signaling and chronic nociceptive behavior.
gp120 Binding (interacts) of ddC associated with nociception, chemokine, acquired immune deficiency syndrome or hiv infection and neuropathic pain
1) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.90 Pain Relevance 0.34
Perineural gp120/hCD4 treatment in combination with ddC produces bilateral mechanical hypernociception
gp120 Binding (treatment) of ddC
2) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.37 Pain Relevance 0.03

General Comments

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