INT281177

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.93
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) lipid metabolic process (Insig1)
Anatomy Link Frequency
CAR 1
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 117 96.24 Very High Very High Very High
Bile 14 91.12 High High
Crohn's disease 1 22.12 Low Low
Inflammation 1 19.60 Low Low
anesthesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 98.96 Very High Very High Very High
Hyperglycemia 54 98.00 Very High Very High Very High
Diabetes Mellitus 55 83.60 Quite High
Injury 6 79.20 Quite High
Obesity 6 47.04 Quite Low
Disease 4 22.12 Low Low
INFLAMMATION 1 19.60 Low Low
Body Weight 16 5.00 Very Low Very Low Very Low
Aging 5 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, BLI is a valid, sensitive, and semi-quantitative technology for monitoring insulin gene expression when used in combination with transgenic mice expressing reporter gene luciferase under the regulation of the insulin gene promoter.
Regulation (regulation) of insulin gene associated with targeted disruption and imagery
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.23 Pain Relevance 0.08
The cross-reactivity of lipid homeostasis and xenobiotic metabolism pathways was recently pin-pointed to converge at the transcription factor Insig-1 being regulated via both CAR and PXR [14].
Regulation (regulated) of Insig-1 in CAR
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.12
A highly conserved region approximately 400 bp immediately upstream of the transcription initiation start site confers both tissue-specific expression and metabolic regulation of the insulin gene [3].
Regulation (regulation) of insulin gene
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.12 Pain Relevance 0
To do this, we induced hyperglycemia by streptozotocin (STZ) treatment in transgenic mice that express the firefly luciferase under the regulation of the 760 bp rat-insulin gene I-promoter.
Regulation (regulation) of rat-insulin gene I-promoter associated with targeted disruption and hyperglycemia
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.58 Pain Relevance 0.12

General Comments

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