INT28118

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 12.24
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Anatomy Link Frequency
poly 2
neck 1
brain 1
fibroblast 1
head 1
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 3 99.12 Very High Very High Very High
Cholecystokinin 6 88.24 High High
fibrosis 35 86.32 High High
Central nervous system 2 75.00 Quite High
antagonist 1 57.68 Quite High
anesthesia 11 41.68 Quite Low
cytokine 22 28.64 Quite Low
Pain 6 25.00 Low Low
abdominal pain 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 295 100.00 Very High Very High Very High
Carcinoma 4 100.00 Very High Very High Very High
Cancer 94 99.92 Very High Very High Very High
Apoptosis 41 99.68 Very High Very High Very High
Stomach Cancer 30 97.80 Very High Very High Very High
Recurrence 105 97.16 Very High Very High Very High
Malignant Neoplastic Disease 39 96.48 Very High Very High Very High
Telangiectasia 199 95.28 Very High Very High Very High
Solid Tumor 8 93.60 High High
Adenocarcinoma 57 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of variance in ATM with adverse side effects of radiotherapy
ATM Binding (Association) of
1) Confidence 0.38 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.88 Pain Relevance 0.04
Enhancement of tumour apoptosis by irradiation combined with ATM AS-ODNs treatment in vivo
ATM Binding (combined) of associated with cancer and apoptosis
2) Confidence 0.37 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 1.09 Pain Relevance 0
One key question derived from the previous results concern the functional consequences of the interaction between PARP-1 and ATM and between poly (ADP-ribosyl)ation and ATM on ATM activation.
ATM Binding (interaction) of in poly
3) Confidence 0.37 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.08 Pain Relevance 0
One key question derived from the previous results concern the functional consequences of the interaction between PARP-1 and ATM and between poly (ADP-ribosyl)ation and ATM on ATM activation.
ATM Binding (interaction) of in poly
4) Confidence 0.37 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.07 Pain Relevance 0
PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers.
ATM Binding (bound) of
5) Confidence 0.35 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers.
ATM Binding (recognize) of
6) Confidence 0.35 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
CCK8-induced antinociception and satiety were significantly reversed by ATM in those doses. [125I]CCK8 binding to the brain slices was observed autoradiographically.
ATM Binding (binding) of in brain associated with antinociception
7) Confidence 0.34 Published 1989 Journal Brain Res. Section Abstract Doc Link 2720404 Disease Relevance 0 Pain Relevance 0.61
Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence

Background

ATM Binding (association) of associated with breast cancer and recurrence
8) Confidence 0.34 Published 2007 Journal Radiat Oncol Section Title Doc Link PMC1971057 Disease Relevance 0.86 Pain Relevance 0
Studying the association between sequence variations in the ATM gene and risk of breast cancer in seven family branches [39] found no association with mutations that truncate the ATM protein in these domains.
ATM Neg (no) Binding (association) of associated with breast cancer
9) Confidence 0.34 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.77 Pain Relevance 0
Association of heterozygosity of the ATM gene with adverse side effects of radiotherapy and risk for ipsilateral breast tumour recurrence (IBTR)
ATM Binding (Association) of associated with breast cancer and recurrence
10) Confidence 0.34 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 1.09 Pain Relevance 0.03
The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding domain in the N-terminal of the protein necessary for activation of p53 in response to DNA damage, 3)the FAT domain – common for the PI3K-like family members FRAP, ATM and TRAPP, 4) a proline rich region shown to bind c-Abl and 5) an incomplete leucine zipper.
ATM Binding (bind) of
11) Confidence 0.33 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.33 Pain Relevance 0
In fibroblast cultures, M2 interacts with DDB1/COP9/cullin repair complex and ATM to suppress DNA-damage induced apoptosis [28].
ATM Binding (interacts) of in fibroblast associated with apoptosis
12) Confidence 0.19 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.21 Pain Relevance 0
ATM has also been implicated in breast, lung, head and neck carcinoma, and is associated with a poor prognosis in adult patients with advanced gastric cancer [11].
ATM Binding (associated) of in neck associated with carcinoma and stomach cancer
13) Confidence 0.03 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 2.29 Pain Relevance 0
ATM has also been implicated in breast, lung, head and neck carcinoma, and is associated with a poor prognosis in adult patients with advanced gastric cancer [11].
ATM Binding (associated) of in lung associated with carcinoma and stomach cancer
14) Confidence 0.01 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 2.29 Pain Relevance 0
ATM has also been implicated in breast, lung, head and neck carcinoma, and is associated with a poor prognosis in adult patients with advanced gastric cancer [11].
ATM Binding (associated) of in head associated with carcinoma and stomach cancer
15) Confidence 0.01 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 2.29 Pain Relevance 0

General Comments

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