INT28122

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2011
Negated 5
Speculated 4
Reported most in Body
Documents 111
Total Number 115
Disease Relevance 26.83
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSC) DNA binding (MSC)
Anatomy Link Frequency
MSC 8
HGF 4
neural 3
MSC 3
brain 2
MSC (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 67 99.84 Very High Very High Very High
Opioid 25 99.56 Very High Very High Very High
cytokine 268 98.72 Very High Very High Very High
Pain 50 98.36 Very High Very High Very High
chemokine 76 98.28 Very High Very High Very High
COX2 13 98.00 Very High Very High Very High
Inflammation 227 96.92 Very High Very High Very High
intrathecal 8 96.80 Very High Very High Very High
Dopamine 17 96.00 Very High Very High Very High
Neurotransmitter 73 94.36 High High
Disease Link Frequency Relevance Heat
Aging 127 99.92 Very High Very High Very High
Glioma 60 99.92 Very High Very High Very High
Multiple Sclerosis 74 99.84 Very High Very High Very High
Obesity 534 99.70 Very High Very High Very High
Nervous System Injury 6 99.48 Very High Very High Very High
Hepatocellular Cancer 188 98.80 Very High Very High Very High
Hypoxia 7 98.80 Very High Very High Very High
Brain Tumor 294 98.72 Very High Very High Very High
Cirrhosis 188 98.52 Very High Very High Very High
Pain 38 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSC produces a treatment plan with predictable responses to the changing decisions and problems that patients express and therefore maximizes the goal of individualized care.
Gene_expression (produces) of MSC
1) Confidence 0.58 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851064 Disease Relevance 0 Pain Relevance 0
Patients express a mix of positive and negative reactions to MSC—often simultaneously.
Gene_expression (express) of MSC
2) Confidence 0.58 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851064 Disease Relevance 0.14 Pain Relevance 0.03
One group of patients (n = 28) as transferred to MSC from weak opioids because of inadequate pain control.
Gene_expression (transferred) of MSC associated with pain and opioid
3) Confidence 0.58 Published 1989 Journal Cancer Section Abstract Doc Link 2720582 Disease Relevance 0.23 Pain Relevance 0.72
Is the bone repair boosted by the injected MSC or by other components of the BM aspirate like growth factors?
Gene_expression (injected) of MSC
4) Confidence 0.54 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.09 Pain Relevance 0
Several methods could be used to increase MSC population and its osteogenic differentiation in the pathological area:
Gene_expression (population) of MSC
5) Confidence 0.54 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.55 Pain Relevance 0
Those adherent cells expressed the characteristic MSC antigens and regained the ability to differentiate into multiple mesodermal lineages.
Gene_expression (expressed) of MSC
6) Confidence 0.50 Published 2008 Journal Stem Cells Dev. Section Abstract Doc Link 18426339 Disease Relevance 0.05 Pain Relevance 0.14
MSC can be found mainly in bone marrow, but also in fat tissue, synovium, periosteum, skeletal muscles, and umbilical cord.
Gene_expression (found) of MSC in periosteum
7) Confidence 0.48 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.39 Pain Relevance 0
Expression profiling of MSC during osteogenic differentiation reveals distinct phases of osteogenic development
Gene_expression (Expression) of MSC
8) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.27 Pain Relevance 0.07
These MSC-derived neurospheres expressed characteristic NSC antigens, such as nestin and musashi-1, and were capable of self-renewal and multilineage differentiation into neurons, astrocytes, and oligodendrocytes.
Gene_expression (expressed) of MSC in oligodendrocytes
9) Confidence 0.44 Published 2008 Journal Stem Cells Dev. Section Abstract Doc Link 18426339 Disease Relevance 0.16 Pain Relevance 0.10
Campard and colleagues reported that a small proportion of umbilical cord-derived MSC expressed albumin, as shown by flow cytometry.
Gene_expression (expressed) of MSC
10) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0
As confirm by other group, we have previously demonstrated that before any differentiation MSC can express specific neural proteins [14,15].
Gene_expression (express) of MSC in neural
11) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.16
In fact, undifferentiated BM-MSC can express a large number of antigens from other tissues in which they reside [14,28-30].
Gene_expression (express) of BM-MSC
12) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.14 Pain Relevance 0.07
The protein expression profiles of MSC and osteoblasts revealed an important decreased expression of calmodulin, calponin, calpain, caldesmon and many others, after differentiation of MSC [32].
Gene_expression (expression) of MSC in osteoblasts
13) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0
In this study, to confirm the differentiation of MSC to neural phenotype and to demonstrate that this differentiation is not an artifact, we performed microarray analysis to establish the gene expression profile of MSC before and after neurogenic differentiation.
Gene_expression (expression) of MSC in neural
14) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.05 Pain Relevance 0.16
Ex vivo differentiation of human bone marrow-derived MSC in osteoblasts and adipocytes
Gene_expression (derived) of MSC in adipocytes associated with obesity
15) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.10 Pain Relevance 0.07
In sum, these results show that long-term expansion of MSC did not alter their differentiation potential, surface marker profiles, and expression profiles.


Gene_expression (expression) of MSC
16) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.22 Pain Relevance 0.08
Human MSC maintain their undifferentiated phenotype during long-term expansion
Gene_expression (maintain) of MSC
17) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
Comparing the gene expression profile of human MSC with CD34 positive cells, Silva et al demonstrated that some genes were exclusively or highly represented in MSC (Collagen type I, Fibronectin, MYL9, Biglycan) [18].
Gene_expression (expression) of MSC
18) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.26 Pain Relevance 0
In vitro, adult and pediatric MSC expressed characteristic surface antigens of MSC.
Gene_expression (expressed) of MSC in MSC
19) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722022 Disease Relevance 0.37 Pain Relevance 0.03
When cultured in hepatogenic differentiation medium alone or co-cultured with Huh-7 cells in differentiation medium, aMSC and more importantly pMSC expressed ?
Gene_expression (expressed) of aMSC
20) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0

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