INT28123

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 4.02
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSC) DNA binding (MSC)
Anatomy Link Frequency
HGF 4
liver parenchyma 4
adipocytes 3
blood 2
hepatocytes 2
MSC (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 8 100.00 Very High Very High Very High
Opioid 3 99.56 Very High Very High Very High
Pain 11 98.36 Very High Very High Very High
cytokine 96 94.64 High High
Inflammatory stimuli 20 90.40 High High
Inflammation 95 85.76 High High
Morphine 4 82.72 Quite High
analgesia 2 78.80 Quite High
dexamethasone 28 76.40 Quite High
fibrosis 50 67.28 Quite High
Disease Link Frequency Relevance Heat
Glioma 10 99.64 Very High Very High Very High
Obesity 72 99.20 Very High Very High Very High
Pain 8 98.36 Very High Very High Very High
Cancer 66 90.48 High High
INFLAMMATION 115 90.40 High High
Toxicity 5 88.92 High High
Necrosis 42 87.84 High High
Injury 49 84.56 Quite High
Nicotine Addiction 2 83.76 Quite High
Genetic Predisposition To Disease 2 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One group of patients (n = 28) as transferred to MSC from weak opioids because of inadequate pain control.
Positive_regulation (transferred) of Gene_expression (transferred) of MSC associated with pain and opioid
1) Confidence 0.43 Published 1989 Journal Cancer Section Abstract Doc Link 2720582 Disease Relevance 0.23 Pain Relevance 0.72
Is the bone repair boosted by the injected MSC or by other components of the BM aspirate like growth factors?
Positive_regulation (injected) of Gene_expression (injected) of MSC
2) Confidence 0.40 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.09 Pain Relevance 0
Several methods could be used to increase MSC population and its osteogenic differentiation in the pathological area:
Positive_regulation (increase) of Gene_expression (population) of MSC
3) Confidence 0.40 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.55 Pain Relevance 0
Ex vivo differentiation of human bone marrow-derived MSC in osteoblasts and adipocytes
Positive_regulation (derived) of Gene_expression (derived) of MSC in adipocytes associated with obesity
4) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.10 Pain Relevance 0.07
First, aMSC and pMSC were seeded on 1% Matrigel (BD Biosciences, Allschwil, Switzerland) at a concentration of 20?
Positive_regulation (concentration) of Gene_expression (seeded) of aMSC
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0.03
In order to analyze effects of liver parenchyma on MSC, we injected aMSC and pMSC directly into liver parenchyma.
Positive_regulation (injected) of Gene_expression (injected) of aMSC in liver parenchyma
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.23 Pain Relevance 0
Pediatric MSC co-cultured with Huh-7 cells express more frequently albumin and alpha 1 anti-trypsin compared to adult MSC
Positive_regulation (frequently) of Gene_expression (express) of MSC
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.05 Pain Relevance 0
In contrast, co-culture with Huh-7 cells induced albumin expression in aMSC and pMSC.
Positive_regulation (induced) of Gene_expression (expression) of pMSC
8) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.31 Pain Relevance 0
A two-step protocol, using hepatocyte growth factor (HGF) and oncostatin M induced hepatocyte specific gene expression in clonal expanded MSC derived from bone marrow and human cord-blood [8].
Positive_regulation (induced) of Gene_expression (expression) of MSC in blood
9) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.40 Pain Relevance 0.06
In contrast, co-culture with Huh-7 cells induced albumin expression in aMSC and pMSC.
Positive_regulation (induced) of Gene_expression (expression) of aMSC
10) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.31 Pain Relevance 0
However, differentiation of MSC into hepatocytes did not occur as well.
Positive_regulation (differentiation) of Gene_expression (differentiation) of MSC in hepatocytes
11) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.08 Pain Relevance 0
In order to analyze effects of liver parenchyma on MSC, we injected aMSC and pMSC directly into liver parenchyma.
Positive_regulation (injected) of Gene_expression (injected) of pMSC in liver parenchyma
12) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.23 Pain Relevance 0
First, aMSC and pMSC were seeded on 1% Matrigel (BD Biosciences, Allschwil, Switzerland) at a concentration of 20?
Positive_regulation (concentration) of Gene_expression (seeded) of pMSC
13) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0.03
Pediatric MSC co-cultured with Huh-7 cells express more frequently albumin and alpha 1 anti-trypsin compared to adult MSC
Positive_regulation (Pediatric) of Gene_expression (express) of MSC
14) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.05 Pain Relevance 0
Strikingly, this prediction was confirmed by an observation that significantly extending length of survival of mice harboring human gliomas is achieved with transplanted MSC carrying IFN-?
Positive_regulation (transplanted) of Gene_expression (transplanted) of MSC associated with glioma
15) Confidence 0.13 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.91 Pain Relevance 0.04
Ex vivo differentiation of human bone marrow-derived MSC in osteoblasts and adipocytes
Positive_regulation (derived) of in osteoblasts Gene_expression (derived) of MSC in adipocytes associated with obesity
16) Confidence 0.10 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.10 Pain Relevance 0.07
For analysis of HGF and PGE2 levels supernatants were obtained from control and primed MSC cultures after 72 hr.
Positive_regulation (primed) of Gene_expression (cultures) of MSC in HGF
17) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0 Pain Relevance 0.20
Expression levels of known MSC immune-modulatory molecules such as IDO, HGF and COX2 generated PGE2 differed in culture supernatants of both the MSCs (Figure 5).
Positive_regulation (generated) of Gene_expression (Expression) of MSC in HGF associated with cox2
18) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.37 Pain Relevance 0.32

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