INT281236

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.36
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Tas2r134)
Anatomy Link Frequency
macrophages 1
astrocytes 1
microglia 1
Tas2r134 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 12 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
Inflammation 58 98.06 Very High Very High Very High
Lasting pain 2 72.28 Quite High
agonist 10 68.64 Quite High
Serotonin 1 64.40 Quite High
bradykinin 2 62.88 Quite High
Pain 19 61.48 Quite High
Glutamate 54 60.72 Quite High
Central nervous system 108 55.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 80 98.06 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 249 94.48 High High
Anxiety Disorder 9 88.92 High High
Neurodegenerative Disease 84 86.56 High High
Pain 22 72.28 Quite High
Infection 102 66.64 Quite High
Ganglion Cysts 10 33.04 Quite Low
Death 38 18.56 Low Low
Apoptosis 6 7.20 Low Low
Stress 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The family of models simultaneously recapitulated the training data and predicted total inositol levels following GPCR activation.
Positive_regulation (activation) of GPCR
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.13 Pain Relevance 0.23
Inflammatory molecules released from microglia/macrophages and astrocytes evoke NMDAR activation, as well as activation of metabotropic glutamate receptors (mGluR), receptor tyrosine kinases (RTK), voltage-gated potassium channels (Kv), other G-protein-coupled receptors (GPCR), and potentially major histocompatability complex subtype 1 receptors (MHC I).
Positive_regulation (activation) of GPCR in astrocytes associated with inflammation, glutamate receptor and potassium channel
2) Confidence 0.05 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.08 Pain Relevance 0.28
Inflammatory molecules released from microglia/macrophages and astrocytes evoke NMDAR activation, as well as activation of metabotropic glutamate receptors (mGluR), receptor tyrosine kinases (RTK), voltage-gated potassium channels (Kv), other G-protein-coupled receptors (GPCR), and potentially major histocompatability complex subtype 1 receptors (MHC I).
Positive_regulation (activation) of GPCR in macrophages associated with inflammation, glutamate receptor and potassium channel
3) Confidence 0.02 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.08 Pain Relevance 0.28
Inflammatory molecules released from microglia/macrophages and astrocytes evoke NMDAR activation, as well as activation of metabotropic glutamate receptors (mGluR), receptor tyrosine kinases (RTK), voltage-gated potassium channels (Kv), other G-protein-coupled receptors (GPCR), and potentially major histocompatability complex subtype 1 receptors (MHC I).
Positive_regulation (activation) of GPCR in microglia associated with inflammation, glutamate receptor and potassium channel
4) Confidence 0.02 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.08 Pain Relevance 0.28

General Comments

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